ArticleThe Journal of experimental medicine1997
Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- The many faceted role of glycogen synthase kinase-3 (GSK-3) in T cells and cancer immunotherapy.Journal of cancer biology · 2024Article
- Novel Compound Heterozygous ZAP70 R37G A507T Mutations in Infant with Severe Immunodeficiency.Journal of clinical immunology · 2023Article
- Regulating the discriminatory response to antigen by T-cell receptor.Bioscience reports · 2022Review
- Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.Journal of neuroinflammation · 2018Article
- Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor.Annals of biomedical engineering · 2016Article
- Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.Molecular and cellular biology · 2013Article
- Quantitative detection of zeta-chain-associated protein 70 expression in chronic lymphocytic leukemia.Leukemia & lymphoma · 2013Article
- Regulation of Syk by phosphorylation on serine in the linker insert.The Journal of biological chemistry · 2010Article
- ZAP-70: an essential kinase in T-cell signaling.Cold Spring Harbor perspectives in biology · 2010Review
- Syk and pTyr'd: Signaling through the B cell antigen receptor.Biochimica et biophysica acta · 2009Review
- Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Efficient gene transfer in CLL by mRNA electroporation.Leukemia · 2008Article
- Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase.Molecular and cellular biology · 2006Article
- Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.Molecular and cellular biology · 2003Article
- Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase.Molecular and cellular biology · 1999Article
- Prolactin receptor signaling: shared components with the T-cell antigen receptor in Nb2 lymphoma cells.Endocrine · 1998Article
- ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation.The Journal of cell biology · 1998Article
- ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration.The Journal of cell biology · 1998Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
To investigate the cellular dynamics of ZAP-70, we have studied the distribution and regulation of its intracellular location using a ZAP-70 green fluorescent protein chimera. Initial experiments in epithelial cells indicated that ZAP-70 is diffusely located throughout the quiescent cell, and accumulates at the plasma membrane upon cellular activation, a phenotype enhanced by the coexpression of Lck and the initiation of ZAP-70 kinase activity. Subsequent studies in T cells confirmed this phenotype. Intriguingly, a large amount of ZAP-70, both chimeric and endogenous, resides in the nucleus of quiescent and activated cells. Nuclear ZAP-70 becomes tyrosine phosphorylated upon stimulation via the T cell receptor, indicating that it may have an important biologic function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.