ArticleMolecular biology of the cell1997
Coordinate regulation of G- and C strand length during new telomere synthesis.
Article in Molecular biology of the cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Structures of human primosome elongation complexes.Nature structural & molecular biology · 2023Article
- CST does not evict elongating telomerase but prevents initiation by ssDNA binding.Nucleic acids research · 2021Article
- Structural and functional impact of non-synonymous SNPs in the CST complex subunit TEN1: structural genomics approach.Bioscience reports · 2019Article
- CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.Nature communications · 2018Article
- Rap1 and Cdc13 have complementary roles in preventing exonucleolytic degradation of telomere 5' ends.Scientific reports · 2017Article
- Sequential phosphorylation of CST subunits by different cyclin-Cdk1 complexes orchestrate telomere replication.Cell cycle (Georgetown, Tex.) · 2017Article
- Structure and function of the telomeric CST complex.Computational and structural biotechnology journal · 2016Review
- Telomere end processing: unexpected complexity at the end game.Genes & development · 2012Article
- Rap1 binds single-stranded DNA at telomeric double- and single-stranded junctions and competes with Cdc13 protein.The Journal of biological chemistry · 2011Article
- Mapping the FEN1 interaction domain with hTERT.Biochemical and biophysical research communications · 2011Article
- Dysfunction of chromatin assembly factor 1 induces shortening of telomeres and loss of 45S rDNA in Arabidopsis thaliana.The Plant cell · 2010Article
- Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase.The EMBO journal · 2009Review
- Article
- Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance.The Journal of biological chemistry · 2009Article
- The role of Stn1p in Saccharomyces cerevisiae telomere capping can be separated from its interaction with Cdc13p.Genetics · 2007Article
- Thermodynamic characterization of binding Oxytricha nova single strand telomere DNA with the alpha protein N-terminal domain.Journal of molecular biology · 2006Article
- Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha.Molecular and cellular biology · 2005Article
- Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.Eukaryotic cell · 2005Article
- Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation.Genes & development · 2004Article
- Replication proteins influence the maintenance of telomere length and telomerase protein stability.Molecular and cellular biology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have used the ciliate Euplotes to study the role of DNA polymerase in telomeric C strand synthesis. Euplotes provides a unique opportunity to study C strand synthesis without the complication of simultaneous DNA replication because millions of new telomeres are made at a stage in the life cycle when no general DNA replication takes place. Previously we showed that the C-strands of newly synthesized telomeres have a precisely controlled length while the G-strands are more heterogeneous. This finding suggested that, although synthesis of the G-strand (by telomerase) is the first step in telomere addition, a major regulatory step occurs during subsequent C strand synthesis. We have now examined whether G- and C strand synthesis might be regulated coordinately rather than by two independent mechanisms. We accomplished this by determining what happens to G- and C strand length if C strand synthesis is partially inhibited by aphidicolin. Aphidicolin treatment caused a general lengthening of the G-strands and a large increase in C strand heterogeneity. This concomitant change in both the G- and C strand length indicates that synthesis of the two strands is coordinated. Since aphidicolin is a very specific inhibitor of DNA pol alpha and pol delta, our results suggest that this coordinate length regulation is mediated by DNA polymerase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.