ArticleThe Biochemical journal1997
Regulation of human prohormone convertase 2 promoter activity by the transcription factor EGR-1.
Article in The Biochemical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Genetic Anatomy and Ontogenetic Roles of Early Growth Response 1 (Egr1) in Human and Mouse.Development & reproduction · 2026Review
- Article
- Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing.The Journal of biological chemistry · 2013Article
- Mechanisms by which the orexigen NPY regulates anorexigenic α-MSH and TRH.American journal of physiology. Endocrinology and metabolism · 2013Article
- Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake.Journal of obesity · 2013Article
- Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs.Frontiers in neuroendocrinology · 2010Review
- Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2.Molecular and cellular biology · 2009Article
- Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2009Article
- Article
- Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone.The Journal of clinical investigation · 2004Article
- Experimental and clinicopathologic study on the relationship between transcription factor Egr-1 and esophageal carcinoma.World journal of gastroenterology · 2001Article
- Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats.The Journal of clinical investigation · 2000Article
- Major Egr3 isoforms are generated via alternate translation start sites and differ in their abilities to activate transcription.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prohormone convertases are involved in the tissue-specific endoproteolytic processing of prohormones and neuropeptide precursors within the secretory pathway. In the present study, we have isolated genomic clones comprising the 5'-terminal region of the human prohormone convertase 2 (PC2) gene and established characteristics of the PC2 promoter region. The proximal promoter region is very G+C-rich and does not contain a canonical TATA box or a CAAT box. Transient expression assays with a set of human PC2 gene fragments containing progressive 5' deletions demonstrate that the proximal promoter region is capable of directing high levels of neuroendocrine-specific expression of reporter gene constructs. In addition, we show that the transcription factor EGR-1 interacts with two distinct elements within the proximal human PC2 promoter region. Transfection experiments also demonstrate that EGR-1 is able to enhance PC2 promoter activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.