ArticleThe Biochemical journal1997
Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene.
Article in The Biochemical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04557176 (TB Screening Improves Preventive Therapy Uptake Trial), which is not on this map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TB Screening Improves Preventive Therapy Uptake Trial
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- C-reactive protein and its ratio with albumin as a marker of poor prognosis in oral cancer: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- Prognostic role of the pretreatment C-reactive protein/albumin ratio in gastric cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Prognostic role of pre-treatment C-reactive protein/albumin ratio in esophageal cancer: a meta-analysis.BMC cancer · 2019Pooled it
- Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet.Diabetes care · 2010Trial
- Effects of partially hydrogenated, semi-saturated, and high oleate vegetable oils on inflammatory markers and lipids.Lipids · 2010Trial
- Differences in Immunological and Inflammatory Biomarkers Levels in People Infected withAdvanced biomedical research · 2026Article
- Nontraumatic Fat Embolism and Fat Embolism Syndrome in Patients with Purulent Bacterial Bronchopneumonia.Journal of clinical medicine · 2025Article
- The seven-day cumulative post-esophagectomy inflammatory response predicts cancer recurrence.BMC surgery · 2024Article
- Effect of intermittent fasting on lipid biokinetics in obese and overweight patients with type 2 diabetes mellitus: prospective observational study.Diabetology & metabolic syndrome · 2024Article
- Exploring the causal relationship between interleukin-6 or C reactive protein and malignant melanoma using a two-sample Mendelian randomization approach.Frontiers in oncology · 2024Review
- C-Reactive Protein Signaling Pathways in Tumor Progression.Biomolecules & therapeutics · 2023Review
- The prognostic significance of preoperative nutritional/inflammatory markers and clinicopathological features in resectable esophagectomy patients: possibility of nutritional intervention.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- Current Status of Antibiotic Stewardship and the Role of Biomarkers in Antibiotic Stewardship Programs.Infection & chemotherapy · 2022Review
- Association between high-sensitivity-CRP and liver elastography and cardiac ischemic diseases in patients with fatty liver.Journal of family medicine and primary care · 2022Article
- Dietary acid load modifies the effects of ApoA2-265 T > C polymorphism on lipid profile and serum leptin and ghrelin levels among type 2 diabetic patients.BMC endocrine disorders · 2022Article
- Branched-Chain Fatty Acids Alter the Expression of Genes Responsible for Lipid Synthesis and Inflammation in Human Adipose Cells.Nutrients · 2022Article
- Changes in plasma-concentration ratios of branched-chain amino acids in acute and convalescent phases of bacterial pneumonia.Journal of clinical biochemistry and nutrition · 2022Article
- Risk factors and predictive markers for early and late-onset neonatal bacteremic sepsis in preterm and term infants.Journal of the Chinese Medical Association : JCMA · 2022Article
- Review
- Ibuprofen use is associated with reduced C-reactive protein and interleukin-6 levels in chronic spinal cord injury.The journal of spinal cord medicine · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the function of different mediators of the regulation of the human C-reactive protein (hCRP) gene in transgenic mice. hCRP was induced by lipopolysaccharide and wounding in interleukin-6 (IL-6) +/+ mice, but not in IL-6 -/- mice. This finding suggested that IL-6 is necessary for the induction of hCRP. However, injection of IL-6 did not induce the hCRP gene. Thus, the induction of hCRP by IL-6 seems to require an additional cofactor. Therefore, we screened different cytokines for their activity in IL-6 +/+ and IL-6 -/- mice. Surprisingly, interleukin-1beta, as well as oncostatin M or leukaemia inhibitory factor, led to an induction of hCRP in both genetic backgrounds. These results indicate an IL-6-dependent and -independent regulation of hCRP. These hCRP transgenic mice therefore represent a novel model system for defining the cytokine network involved in the regulation of acute-phase genes during the course of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.