ReviewDrugs & aging1997
Immunodeficiency of aging.
Review in Drugs & aging, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the Infectious Diseases Society of America.Journal of the American Geriatrics Society · 2009Guideline
- Efficacy of Disease Modifying Therapies in Progressive MS and How Immune Senescence May Explain Their Failure.Frontiers in neurology · 2022Review
- Continued Upward Trend in Non-Tuberculous Mycobacteria Isolation over 13 Years in a Tertiary Care Hospital in Korea.Yonsei medical journal · 2021Article
- Self-reported vaccination in the elderly: SABE Bogota study, Colombia.Colombia medica (Cali, Colombia) · 2016Article
- Activation of Natural Killer Cells by Probiotics.Forum on immunopathological diseases and therapeutics · 2016Article
- Proinflammatory cytokines and DHEA-S in women with fibromyalgia: impact of psychological distress and menopausal status.Journal of pain research · 2014Article
- Effect of influenza on functional decline.Journal of the American Geriatrics Society · 2012Article
- Aging and the pathogenic response to burn.Aging and disease · 2012Article
- Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice.Age (Dordrecht, Netherlands) · 2011Article
- Susceptibility of the aging lung to environmental injury.Seminars in respiratory and critical care medicine · 2010Review
- Multiple sclerosis in the elderly patient.Drugs & aging · 2010Review
- The aging immune system and its relationship to the development of chronic obstructive pulmonary disease.Proceedings of the American Thoracic Society · 2009Review
- A novel role for CD4+ T cells in the control of cachexia.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cachexia in the non-obese diabetic mouse is associated with CD4+ T-cell lymphopenia.Immunology · 2008Article
- Host resistance and immune responses in advanced age.Clinics in geriatric medicine · 2007Review
- The effects of long-term endurance training on the immune and endocrine systems of elderly men: the role of cytokines and anabolic hormones.Immunity & ageing : I & A · 2006Article
- Stress, age, and immune function: toward a lifespan approach.Journal of behavioral medicine · 2006Review
- Dysregulation of T-cell function in the elderly : scientific basis and clinical implications.Drugs & aging · 2005Review
- Associating changes in the immune system with clinical diseases for interpretation in risk assessment.Current protocols in toxicology · 2004Article
- Preliminary studies on the effect of dehydroepiandrosterone (DHEA) on both constitutive and phytohaemagglutinin (PHA)-inducible IL-6 and IL-2 mRNA expression and cytokine production in human spleen mononuclear cell suspensions in vitro.Clinical and experimental immunology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with declines in multiple areas of immune function, but to date no single mechanism has emerged as being responsible for all the observed changes. Many changes occur at different rates within individuals as well as between individuals. With advancing age there is a concomitant increase in the incidence of many infections and cancers. It is being increasingly acknowledged that autoimmune processes play a proinflammatory role in the development of many pathological conditions, such as atherosclerosis. However, direct causal relationships between specific changes in immunity and the occurrence of specific diseases are rare. There is accumulating epidemiological, in vivo and in vitro evidence to support many such direct relationships in both animals and humans. It is likely that the mechanisms underlying age-related changes in immunity are multifactorial, with both genetic and environmental factors playing a significant role. Despite the current lack of unifying theories, much active and exciting work is proceeding in the area of immune stimulation. Studies describing age-related changes in immunity, as well as the testing of interventions to reverse these changes, will continue to fill the gaps in our knowledge, leading to a more comprehensive understanding of immunosenescence.
Indexed as
Identifiers
9359024What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.