ArticleThe American journal of pathology1997
Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 93 citations in OpenAlex.
- Genetics of familial acromegaly and pituitary gigantism.The Journal of clinical endocrinology and metabolism · 2026Review
- Endoscopic endonasal resection of olfactory tract hamartoma for pediatric epilepsy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- The role of TSC1 and TSC2 proteins in neuronal axons.Molecular psychiatry · 2024Review
- Revisiting Brain Tuberous Sclerosis Complex in Rat and Human: Shared Molecular and Cellular Pathology Leads to Distinct Neurophysiological and Behavioral Phenotypes.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Phakomatoses and Endocrine Gland Tumors: Noteworthy and (Not so) Rare Associations.Frontiers in endocrinology · 2021Review
- Tuberous Sclerosis (tsc2+/-) Model Eker Rats Reveals Extensive Neuronal Loss with Microglial Invasion and Vascular Remodeling Related to Brain Neoplasia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- Mechanistic Target of Rapamycin Pathway in Epileptic Disorders.Journal of Korean Neurosurgical Society · 2019Article
- The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth.British journal of clinical pharmacology · 2019Review
- Silent gonadotroph pituitary neuroendocrine tumor in a patient with tuberous sclerosis complex: evaluation of a possible molecular link.Endocrinology, diabetes & metabolism case reports · 2018Article
- Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.Epilepsia · 2012Review
- Novel animal models of pediatric epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Synaptic plasticity and learning in animal models of tuberous sclerosis complex.Neural plasticity · 2012Review
- Animal models of lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC).Lymphatic research and biology · 2010Review
- The tuberous sclerosis complex.Annals of the New York Academy of Sciences · 2010Review
- Animal models of focal cortical dysplasia and tuberous sclerosis complex: recent progress toward clinical applications.Epilepsia · 2009Article
- Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway.Cell cycle (Georgetown, Tex.) · 2009Review
- Genetics and molecular biology of tuberous sclerosis complex.Current genomics · 2008Article
- A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The neurobiology of the tuberous sclerosis complex.Neuromolecular medicine · 2006Review
- Renal carcinogenesis: genotype, phenotype and dramatype.Cancer science · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tuberous sclerosis (TSC) is an autosomal dominant syndrome that is linked to two genetic loci: TSC1 (9q34) and TSC2 (16p13). Brain manifestations such as cortical tubers and subependymal hamartoma/giant cell astrocytomas are major causes of TSC-related morbidity. In this study, we describe the central nervous system involvement in a unique rodent model of tuberous sclerosis. The Eker rat carries a spontaneous germline mutation of the TSC2 gene and is predisposed to multiple neoplasia. In a series of 45 adult Eker carriers (TSC2 +/-), three types of focal intracranial lesions were found, of which the subependymal and subcortical hamartomas were most prevalent (65%). There exist remarkable phenotypic similarities between the Eker rat and human subependymal lesions. Our study indicates that the predominant cellular phenotype of the subependymal hamartomas is astroglial and suggests that the neuronal contribution within these lesions is, in part, the result of pre-existing myelinated axons. The hamartomas did not show evidence of loss of the wild-type TSC2 allele; it remains to be determined whether TSC2 inactivation is necessary for their pathogenesis. This genetically-defined rodent model may be useful in elucidating the molecular and developmental basis of the subependymal giant cell astrocytoma in humans.
Indexed as
Identifiers
9358774PMC1858083W1752565791What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.