ArticleThe American journal of pathology1997
Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 87 citations in OpenAlex.
- Article
- Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells.Nature communications · 2020Article
- Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury.Frontiers in cell and developmental biology · 2019Review
- MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis.Experimental & molecular medicine · 2015Article
- Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models.Journal of cellular and molecular medicine · 2013Review
- Myofibroblast keratinocyte growth factor reduces tight junctional integrity and increases claudin-2 levels in polarized Caco-2 cells.Growth factors (Chur, Switzerland) · 2012Article
- Primary human colonic myofibroblasts are resistant to Clostridium difficile toxin A-induced, but not toxin B-induced, cell death.Infection and immunity · 2011Article
- Characterization of putative stem cells in isolated human colonic crypt epithelial cells and their interactions with myofibroblasts.American journal of physiology. Cell physiology · 2009Article
- Cultured bone marrow cell local implantation accelerates healing of ulcers in mice.Journal of gastroenterology · 2008Article
- A potential role for interleukin-18 in inhibition of the development of Cryptosporidium parvum.Clinical and experimental immunology · 2006Article
- Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response.Journal of gastroenterology · 2005Review
- Altered epithelial cell lineage allocation and global expansion of the crypt epithelial stem cell population are associated with ileitis in SAMP1/YitFc mice.The American journal of pathology · 2005Article
- Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease.The American journal of pathology · 2004Article
- Impaired rejection and mucosal injury of small intestinal allografts lacking the interferon-gamma receptor.International journal of experimental pathology · 2003Article
- Induction of keratinocyte growth factor 1 Expression by lipopolysaccharide is regulated by CD-14 and toll-like receptors 2 and 4.Infection and immunity · 2002Article
- Review
- Possible involvement of neutrophil elastase in impaired mucosal repair in patients with ulcerative colitis.Journal of gastroenterology · 2002Article
- Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis.Gut · 2002Article
- Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease.Gut · 2002Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation in the gastrointestinal tract is associated with increased epithelial cell proliferation. Keratinocyte growth factor (KGF) is an epithelial cell mitogen widely expressed by mesenchymal cells subjacent to the epithelial cells. In this study, we have investigated the expression and distribution of KGF in normal and diseased (Crohn's disease and ulcerative colitis(UC)) intestine by quantitative competitive reverse-transcriptase polymerase chain reaction in whole biopsies and purified lamina propria myofibroblasts and by in situ hybridization. Analysis of whole mucosal biopsies reveals significantly higher numbers of KGF mRNA transcripts in UC compared with Crohn's colitis and control colon (P < 0.001). KGF transcripts were also elevated in Crohn's ileitis compared with normal ileum. In situ hybridization showed a marked increase in cells expressing KGF mRNA throughout the lamina propria in both UC and Crohn's tissue. In Crohn's disease, positively hybridizing cells were only rarely seen in the submucosa but were abundant around the bases of the crypts and were not associated with lymphoid aggregates. In purified mucosal myofibroblasts, increased (15- to 20-fold) KGF mRNA expression was seen in UC compared with control and Crohn's tissue. These results confirm and extend earlier studies showing that KGF transcripts are elevated in inflammatory bowel disease, but they show for the first time that transcripts are higher in UC than Crohn's disease because of increased production by mucosal mesenchymal cells.
Indexed as
Identifiers
9358773PMC1858064W145873825What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.