ArticleThe American journal of pathology1997
Mice lacking the thrombin receptor, PAR1, have normal skin wound healing.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Complement MASP-1 Modifies Endothelial Wound Healing.International journal of molecular sciences · 2024Article
- Beyond thrombosis: the impact of tissue factor signaling in cancer.Journal of hematology & oncology · 2020Review
- MMP-1 overexpression selectively alters inhibition in D1 spiny projection neurons in the mouse nucleus accumbens core.Scientific reports · 2018Article
- From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Anti-inflammatory and protective investigations on the effects of Theranekron® "an alcoholic extract of the Tarantula cubensis" on wound healing of peritoneal in the rat: an in vivo comparative study.Diagnostic pathology · 2015Article
- Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet.The American journal of pathology · 2011Article
- Tissue factor and cell signalling in cancer progression and thrombosis.Journal of thrombosis and haemostasis : JTH · 2011Review
- Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Wound healing in hemophilia B mice and low tissue factor mice.Thrombosis research · 2010Review
- Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice.The American journal of pathology · 2010Article
- Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia.American journal of respiratory cell and molecular biology · 2009Article
- Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.The European journal of neuroscience · 2009Article
- Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome.The Journal of clinical investigation · 2008Article
- Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis.The American journal of pathology · 2005Article
- Wound-healing studies in transgenic and knockout mice.Molecular biotechnology · 2004Review
- Protease activated receptors in cardiovascular function and disease.Molecular and cellular biochemistry · 2004Article
- Mouse embryogenesis requires the tissue factor extracellular domain but not the cytoplasmic domain.The Journal of clinical investigation · 2000Article
- Expression of thrombomodulin and consequences of thrombomodulin deficiency during healing of cutaneous wounds.The American journal of pathology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Thrombin's actions on platelets, macrophages, fibroblasts, and endothelial cells have prompted the hypothesis that thrombin may be important for inflammatory and fibroproliferative processes in wound healing. Protease-activated receptor 1 (PAR1) is a G-protein-coupled receptor that mediates many of the cellular activities of thrombin. To test the role of this receptor in vivo, we generated PAR1-deficient mice. Despite the observation that fibroblasts cultured from these mice lacked responsiveness to thrombin in vitro, we now report that there was no difference detected between wild-type and PAR1-deficient mice in skin wound healing assays including time to closure of open wounds, tensile strength of healed incisional wounds, wound histology, and hydroxyproline/DNA content of wound implants. We conclude that PAR1 is not necessary for normal skin wound healing in mice.
Indexed as
Identifiers
9358744PMC1858088W2279119413What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.