ArticleProceedings of the National Academy of Sciences of the United States of America1997
Transgenic rats reveal functional conservation of regulatory controls between the Fugu isotocin and rat oxytocin genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 101 citations in OpenAlex.
- Hypothalamic MCH Neurons: From Feeding to Cognitive Control.Function (Oxford, England) · 2024Review
- Role of Oxytocin/Vasopressin-Like Peptide and Its Receptor in Vitellogenesis of Mud Crab.International journal of molecular sciences · 2020Article
- Review
- Neurogenetic basis for circadian regulation of metabolism by the hypothalamus.Genes & development · 2019Review
- Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience.Neuroscience and biobehavioral reviews · 2017Review
- Specialized Networks for Social Cognition: A Defining Role for the Oxytocin Receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Evolution of oxytocin pathways in the brain of vertebrates.Frontiers in behavioral neuroscience · 2014Review
- Physiology of invertebrate oxytocin and vasopressin neuropeptides.Experimental physiology · 2014Review
- The relative contribution of proximal 5' flanking sequence and microsatellite variation on brain vasopressin 1a receptor (Avpr1a) gene expression and behavior.PLoS genetics · 2013Article
- Review
- Conservation of gene function in behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types.Frontiers in neural circuits · 2009Article
- Sequence and organization of coelacanth neurohypophysial hormone genes: evolutionary history of the vertebrate neurohypophysial hormone gene locus.BMC evolutionary biology · 2008Article
- The Fugu tyrp1 promoter directs specific GFP expression in zebrafish: tools to study the RPE and the neural crest-derived melanophores.Pigment cell research · 2006Article
- Absence of oxytocin in the central nervous system of the snake Bothrops jararaca.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2006Article
- Defining the mammalian CArGome.Genome research · 2006Article
- Transgenic modifications of the rat genome.Transgenic research · 2005Review
- Regulatory domains in the intergenic region of the oxytocin and vasopressin genes that control their hypothalamus-specific expression in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Insights from human/mouse genome comparisons.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Review
- Conserved regulation of the lymphocyte-specific expression of lck in the Fugu and mammals.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have asked whether comparative genome analysis and rat transgenesis can be used to identify functional regulatory domains in the gene locus encoding the hypothalamic neuropeptides oxytocin (OT) and vasopressin. Isotocin (IT) and vasotocin (VT) are the teleost homologues of these genes. A contiguous stretch of 46 kb spanning the Fugu IT-VT locus has been sequenced, and nine putative genes were found. Unlike the OT and vasopressin genes, which are closely linked in the mammalian genome in a tail-to-tail orientation, Fugu IT and VT genes are linked head to tail and are separated by five genes. When a cosmid containing the Fugu IT-VT locus was introduced into the rat genome, we found that the Fugu IT gene was specifically expressed in rat hypothalamic oxytocinergic neurons and mimicked the response of the endogenous OT gene to an osmotic stimulus. These data show that cis-acting elements and trans-acting factors mediating the cell-specific and physiological regulation of the OT and IT genes are conserved between mammals and fish. The combination of Fugu genome analysis and transgenesis in a mammal is a powerful tool for identifying and analyzing conserved vertebrate regulatory elements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.