ArticleProceedings of the National Academy of Sciences of the United States of America1997
Control of alternative pre-mRNA splicing by distributed pentameric repeats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment.Molecular and cellular biology · 2012Article
- PTPN22 polymorphisms may indicate a role for this gene in atopic dermatitis in West Highland white terriers.BMC research notes · 2011Article
- Autoregulation of Fox protein expression to produce dominant negative splicing factors.RNA (New York, N.Y.) · 2010Article
- Fox-1 family of RNA-binding proteins.Cellular and molecular life sciences : CMLS · 2009Review
- Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation.Blood · 2008Article
- The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.Molecular and cellular biology · 2007Article
- ADAM15 gene structure and differential alternative exon use in human tissues.BMC molecular biology · 2007Article
- Alternative splicing events identified in human embryonic stem cells and neural progenitors.PLoS computational biology · 2007Article
- Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements.PLoS genetics · 2007Article
- Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing.Molecular and cellular biology · 2007Article
- Intronic alternative splicing regulators identified by comparative genomics in nematodes.PLoS computational biology · 2006Article
- Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice.Molecular and cellular biology · 2006Article
- Molecular basis of RNA recognition by the human alternative splicing factor Fox-1.The EMBO journal · 2006Article
- Unusual intron conservation near tissue-regulated exons found by splicing microarrays.PLoS computational biology · 2006Article
- Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals.Molecular and cellular biology · 2005Article
- Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities.Nucleic acids research · 2005Article
- The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons.Nucleic acids research · 2005Article
- Variation in sequence and organization of splicing regulatory elements in vertebrate genes.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple copies of the hexamer TGCATG have been shown to regulate fibronectin pre-mRNA alternative splicing. GCATG repeats also are clustered near the regulated calcitonin-specific 3' splice site in the rat calcitonin/CGRP gene. Specific mutagenesis of these repeats in calcitonin/CGRP pre-mRNA resulted in the loss of calcitonin-specific splicing, suggesting that the native repeats act to enhance alternative exon inclusion. Mutation of subsets of these elements implies that alternative splicing requires a minimum of two repeats, and that the combination of one intronic and one exonic repeat is necessary for optimal cell-specific splicing. However, multimerized intronic repeats inhibited calcitonin-specific splicing in both the wild-type context and in a transcript lacking endogenous repeats. These results suggest that both the number and distribution of repeats may be important features for the regulation of tissue-specific alternative splicing. Further, RNA containing a single repeat bound cell-specific protein complexes, but tissue-specific differences in protein binding were not detected by using multimerized repeats. Together, these data support a novel model for alternative splicing regulation that requires the cell-specific recognition of multiple, distributed sequence elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.