Evidence map›Paper›PMID 9354268›Full record

ArticleVirus genes1997

Sequence analysis demonstrates that VP6, NSP1 and NSP4 genes of Indian neonatal rotavirus strain 116E are of human origin.

N A Cunliffe, B K Das, M Ramachandran, M K Bhan, R I Glass, J R Gentsch

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Virus genes, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Rotavirus vaccines: an overview.Clinical microbiology reviews · 2008
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

N A CunliffeDivision of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, USA.
B K Das
M Ramachandran
M K Bhan
R I Glass
J R Gentsch
All India Institute of Medical Sciences · INNational Center for Infectious Diseases · USCenters for Disease Control and Prevention · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

We have sequenced the genes encoding the inner capsid protein VP6 and the nonstructural proteins NSP1 and NSP4 of the Indian neonatal serotype P8[11]G9 human/bovine reassortant candidate vaccine rotavirus strain 116E. These three genes share a high degree of sequence and deduced amino acid homology with human prototype strain Wa. Our results confirm and extend those of previous RNA-RNA hybridization studies which suggested that these genes are of human origin, and will facilitate examination of the host immune response to 116E induced by natural infection and vaccination.

Indexed as

Antigens, ViralCapsid ProteinsGenes, ViralSequence AnalysisAmino Acid SequenceCapsidConserved SequenceGlycoproteinsHumansIndiaInfant, NewbornMolecular Sequence DataOpen Reading FramesRotavirusSequence Homology, Amino AcidToxins, BiologicalAntigens, ViralCapsid ProteinsGlycoproteinsNS28 protein, rotavirusnsp1 protein, RotavirusToxins, BiologicalViral Nonstructural ProteinsViral Structural ProteinsVP6 protein, Rotavirus

Identifiers

PMID9354268
OpenAlexW314035463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.