ArticleInfection and immunity1997
Mycobacterial growth and sensitivity to H2O2 killing in human monocytes in vitro.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
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- Efferocytosis of Apoptotic Neutrophils Enhances Control of Mycobacterium tuberculosis in HIV-Coinfected Macrophages in a Myeloperoxidase-Dependent Manner.Journal of innate immunity · 2020Article
- Vacuoles of Candida yeast as a specialized niche for Helicobacter pylori.World journal of gastroenterology · 2014Review
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- Does M. tuberculosis genomic diversity explain disease diversity?Drug discovery today. Disease mechanisms · 2010Article
- Impaired activation of Stat1 and c-Jun as a possible defect in macrophages of patients with active tuberculosis.Clinical and experimental immunology · 2009Article
- Transcriptional analysis of Mycobacterium fortuitum cultures upon hydrogen peroxide treatment using the novel standard rrnA-P1.BMC microbiology · 2008Article
- Tactics of Mycobacterium avium subsp. paratuberculosis for intracellular survival in mononuclear phagocytes.Journal of veterinary science · 2008Review
- Evidence for positive selection on Mycobacterium tuberculosis within patients.BMC evolutionary biology · 2004Article
- Reactive nitrogen intermediates have a bacteriostatic effect on Mycobacterium tuberculosis in vitro.Journal of clinical microbiology · 2002Article
- Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro.Infection and immunity · 2002Article
- Recent advances in our understanding of human host responses to tuberculosis.Respiratory research · 2001Review
- Necrosis of lung epithelial cells during infection with Mycobacterium tuberculosis is preceded by cell permeation.Infection and immunity · 2000Article
- Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro.Infection and immunity · 1999Article
- Generation of multinucleated giant cells in vitro by culture of human monocytes with Mycobacterium bovis BCG in combination with cytokine-containing supernatants.Infection and immunity · 1999Article
- Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum.Journal of bacteriology · 1998Article
- Mycobacterium avium-intracellulare contamination of mammalian cell cultures.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The intracellular growth and susceptibilities to killing by H2O2 in cultured human monocytes of a number of mycobacterial species including laboratory strains and clinical isolates of Mycobacterium tuberculosis, and Mycobacterium bovis bacillus Calmette-Guerin (BCG) and a clinical isolate of Mycobacterium avium-M. intracellulare were examined. The clinical isolate of M. avium-M. intracellulare did not replicate in freshly explanted monocytes (generation time of >400 h); BCG replicated with a generation time of 95 h, and M. tuberculosis strains CDC551, H37Rv, and H37Ra replicated with generation times of 24, 35, and 37 h, respectively, during the 4-day growth assay. When cultured in monocytes for 4 days, the mycobacteria were variably sensitive to H2O2-induced killing. A positive correlation between the generation time and percent killing of intracellular bacilli was observed. By comparison, mycobacterial strains were similarly sensitive to H2O2 treatment in cell-free culture media and in sonicated cell suspensions. Using a number of inhibitors of reactive oxygen intermediates we determined that other than catalase the inhibitors tested did not affect H2O2-induced killing of intracellular mycobacteria. Our studies suggest that the killing of mycobacteria growing in human monocytes in vitro by the addition of exogenous H2O2 is dependent on the susceptibility to a peroxide-induced killing pathway as well as on the intracellular growth rate of the mycobacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.