ArticleInfection and immunity1997
Cloning and disruption of the antigenic catalase gene of Aspergillus fumigatus.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 130 citations in OpenAlex.
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- The Oxidative Stress Response Highly Depends on Glucose and Iron Availability inJournal of fungi (Basel, Switzerland) · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Cytosol Peroxiredoxin and Cell Surface Catalase Differentially Respond to HAntioxidants (Basel, Switzerland) · 2023Article
- Comparative proteome analysis identifies species-specific signature proteins in Aspergillus pathogens.Applied microbiology and biotechnology · 2023Article
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- The Gβ-like ProteinJournal of fungi (Basel, Switzerland) · 2022Article
- A secreted catalase contributes to Puccinia striiformis resistance to host-derived oxidative stress.Stress biology · 2021Article
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- Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi.Lasers in medical science · 2019Article
- Analyses of the three 1-Cys Peroxiredoxins from Aspergillus fumigatus reveal that cytosolic Prx1 is central to HScientific reports · 2018Article
- Enzymatic Mechanisms Involved in Evasion of Fungi to the Oxidative Stress: Focus on Scedosporium apiospermum.Mycopathologia · 2018Review
- Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.Antimicrobial agents and chemotherapy · 2017Article
- Characteristics of a Regulator of G-Protein Signaling (RGS)Frontiers in microbiology · 2017Article
- rtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatus.PloS one · 2017Article
- SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus.PLoS pathogens · 2016Article
- The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance.Journal of microbiology (Seoul, Korea) · 2016Review
- Genome Sequencing and Comparative Genomics Analysis Revealed Pathogenic Potential inFrontiers in microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus fumigatus possesses two catalases (described as fast and slow on the basis of their electrophoretic mobility). The slow catalase has been recognized as a diagnostic antigen for aspergillosis in immunocompetent patients. The antigenic catalase has been purified. The enzyme is a tetrameric protein composed of 90-kDa subunits. The corresponding cat1 gene was cloned, and sequencing data show that the cat1 gene codes for a 728-amino-acid polypeptide. A recombinant protein expressed in Pichia pastoris is enzymatically active and has biochemical and antigenic properties that are similar to those of the wild-type catalase. Molecular experiments reveal that CAT1 contains a signal peptide and a propeptide of 15 and 12 amino acid residues, respectively. cat1-disrupted mutants that were unable to produce the slow catalase were as sensitive to H2O2 and polymorphonuclear cells as the wild-type strain. In addition, there was no difference in pathogenicity between the cat1 mutant and its parental cat1+ strain in a murine model of aspergillosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.