ReviewCurrent topics in developmental biology1998
Meiotic recombination hotspots: shaping the genome and insights into hypervariable minisatellite DNA change.
Review in Current topics in developmental biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Insights into the architecture of earthworm metallothionein genes, powered by long-read genomics and transcriptomics.NAR genomics and bioinformatics · 2026Article
- The evolutionary entanglement of flipons with zinc fingers and retroelements has engendered a large family of Z-DNA and G-quadruplex binding proteins.Open biology · 2025Article
- Article
- Genetic and epigenetic determinants mediate proneness of oncogene breakpoint sites for involvement in TCR translocations.Genes and immunity · 2014Article
- iRSpot-TNCPseAAC: identify recombination spots with trinucleotide composition and pseudo amino acid components.International journal of molecular sciences · 2014Article
- Models for chromosomal replication-independent non-B DNA structure-induced genetic instability.Molecular carcinogenesis · 2009Review
- Phosphorylation-independent regulation of Atf1-promoted meiotic recombination by stress-activated, p38 kinase Spc1 of fission yeast.PloS one · 2009Article
- Meiotic recombination hotspots of fission yeast are directed to loci that express non-coding RNA.PloS one · 2008Article
- Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26.Molecular biology of the cell · 2008Article
- Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis.Genome dynamics and stability · 2008Article
- Multiple modes of chromatin configuration at natural meiotic recombination hot spots in fission yeast.Eukaryotic cell · 2007Article
- Effects of trans-acting genetic modifiers on meiotic recombination across the a1-sh2 interval of maize.Genetics · 2006Article
- Differential activation of M26-containing meiotic recombination hot spots in Schizosaccharomyces pombe.Genetics · 2005Article
- Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells.Molecular and cellular biology · 2004Article
- Reciprocal and nonreciprocal recombination at the glucocerebrosidase gene region: implications for complexity in Gaucher disease.American journal of human genetics · 2003Article
- The comprehensive mouse radiation hybrid map densely cross-referenced to the recombination map: a tool to support the sequence assemblies.Genome research · 2003Article
- High-resolution patterns of meiotic recombination across the human major histocompatibility complex.American journal of human genetics · 2002Article
- Article
- GT repeats are associated with recombination on human chromosome 22.Genome research · 2000Article
- Purification and characterization of a novel human acidic nuclease/intra-cyclobutyl-pyrimidine-dimer-DNA phosphodiesterase.The Biochemical journal · 2000Article
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1 author at 1 institution in 1 country.
Funding
Abstract
Meiotic homologous recombination serves three principal roles. First, recombination reassorts the linkages between newly-arising alleles to provide genetic diversity upon which natural selection can act. Second, recombination is used to repair certain types of DNA damage to provide a mechanism of genomic homeostasis. Third, with few exceptions homologous recombination is required for the appropriate segregation of homologous chromosomes during meiosis. Recombination rates are elevated near DNA sites called "recombination hotspots." These sites influence the distribution of recombination along chromosomes and the timing of recombination during the life cycle. Recent advances have revealed biochemical steps of hotspot activation and have suggested that hotspots may regulate when and where recombination occurs. Two models for hotspot activation, one in which hotspots act early in the recombination pathway and one in which hotspots act late in the recombination pathway, are presented. The latter model can account for changes at hypervariable minisatellite DNA in metazoan genomes by invoking resolution of Holliday junctions at minisatellite DNA repeats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.