ArticleThe EMBO journal1997
MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 77 citations in OpenAlex.
- Functional Roles of Src Kinase Activity in Oocyte Maturation and Artificial Egg Activation inCells · 2026Article
- The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop.Nature communications · 2021Article
- Anticancer Activities of Meroterpenoids Isolated from the Brown AlgaFoods (Basel, Switzerland) · 2020Article
- Oncogenic Ras suppresses Cdk1 in a complex manner during the incubation of activated Xenopus egg extracts.Archives of biochemistry and biophysics · 2013Article
- Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.The Journal of biological chemistry · 2012Article
- Mitogen-activated protein kinase kinase 1-dependent Golgi unlinking occurs in G2 phase and promotes the G2/M cell cycle transition.Molecular biology of the cell · 2007Article
- Deciphering the H-Ras pathway in Xenopus oocyte.Oncogene · 2006Article
- Mechanistic studies of the mitotic activation of Mos.Molecular and cellular biology · 2006Article
- Article
- Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis.Molecular and cellular biology · 2002Article
- Cyclin B/cdc2 induces c-Mos stability by direct phosphorylation in Xenopus oocytes.Molecular biology of the cell · 2001Article
- c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Mos activates MAP kinase in mouse oocytes through two opposite pathways.The EMBO journal · 2000Article
- Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.Molecular and cellular biology · 2000Article
- Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes.The EMBO journal · 2000Article
- Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts.Molecular biology of the cell · 2000Article
- Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells.Molecular biology of the cell · 1999Article
- Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Mos positively regulates Xe-Wee1 to lengthen the first mitotic cell cycle of Xenopus.Genes & development · 1999Article
- Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Down-regulation of MAP kinase (MAPK) is a universal consequence of fertilization in the animal kingdom, although its role is not known. Here we show that MAPK inactivation is essential for embryos, both vertebrate and invertebrate, to enter first mitosis. Suppressing down-regulation of MAPK at fertilization, for example by constitutively activating the upstream MAPK cascade, specifically suppresses cyclin B-cdc2 kinase activation and its consequence, entry into first mitosis. It thus appears that MAPK functions in meiotic maturation by preventing unfertilized eggs from proceeding into parthenogenetic development. The most general effect of artificially maintaining MAPK activity after fertilization is prevention of the G2 to M-phase transition in the first mitotic cell cycle, even though inappropriate reactivation of MAPK after fertilization may lead to metaphase arrest in vertebrates. Advancing the time of MAPK inactivation in fertilized eggs does not, however, speed up their entry into first mitosis. Thus, sustained activity of MAPK during part of the first mitotic cell cycle is not responsible for late entry of fertilized eggs into first mitosis.
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