ArticleThe EMBO journal1997
Branched O-linked oligosaccharides ectopically expressed in transgenic mice reduce primary T-cell immune responses.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 89 citations in OpenAlex.
- Genome-scale CRISPR activation screen uncovers tumor-intrinsic modulators of CD3 bispecific antibody efficacy.Scientific reports · 2019Article
- Cosmc is required for T cell persistence in the periphery.Glycobiology · 2019Article
- Distinctive Surface Glycosylation Patterns Associated With Mouse and Human CD4Frontiers in immunology · 2017Article
- Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells.The Journal of experimental medicine · 2012Article
- Golgi phosphoprotein 3 determines cell binding properties under dynamic flow by controlling Golgi localization of core 2 N-acetylglucosaminyltransferase 1.The Journal of biological chemistry · 2012Article
- A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans.The EMBO journal · 2011Article
- The glycosylation status of murine [corrected] postnatal thymus: a study by histochemistry and lectin blotting.Journal of molecular histology · 2008Article
- Mucin biosynthesis: identification of the cis-regulatory elements of human C2GnT-M gene.American journal of respiratory cell and molecular biology · 2007Article
- A multipotential beta -1,6-N-acetylglucosaminyl-transferase is encoded by bovine herpesvirus type 4.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans.The Journal of experimental medicine · 2000Article
- Expression of human Wiskott-Aldrich syndrome protein in patients' cells leads to partial correction of a phenotypic abnormality of cell surface glycoproteins.Gene therapy · 2000Article
- Dual roles of sialyl Lewis X oligosaccharides in tumor metastasis and rejection by natural killer cells.The EMBO journal · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GnT, is a key enzyme in O-linked oligosaccharide (O-glycan) biosynthesis and the resultant core 2 branch serves as a backbone for additional glycosylation to form oligosaccharide ligands such as sialyl Le(x). Since the expression of C2GnT is highly regulated during T-cell development and increases in pathological conditions such as the Wiskott-Aldrich syndrome, we have generated transgenic mice overexpressing C2GnT in the T-cell lineage. Surprisingly, T lymphocytes in the transgenic mice develop normally, but they exhibit a reduced immune response when assayed by delayed-type hypersensitivity, proliferation upon stimulation and cytokine production. Moreover, T lymphocytes from the transgenic mice adhere much less efficiently to ICAM-1 and fibronectin than do T lymphocytes from non-transgenic mice. These results indicate that overexpression of the core 2 branched O-glycans in T lymphocytes results in reduced immune responses due to impaired cell-cell interaction. Such an impaired immune response may be one of the causes for immunodeficiency in the Wiskott-Aldrich syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.