ArticleThe Journal of physiology1997
Immunoglobulins from motoneurone disease patients enhance glutamate release from rat hippocampal neurones in culture.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
- The Pathway-Selective Dependence of Nitric Oxide for Long-Term Potentiation in the Anterior Cingulate Cortex of Adult Mice.Biomedicines · 2024Article
- Immunology of amyotrophic lateral sclerosis - role of the innate and adaptive immunity.Frontiers in neuroscience · 2023Review
- Computational Modeling of Inhibitory Transsynaptic Signaling in Hippocampal and Cortical Neurons Expressing Intrabodies Against Gephyrin.Frontiers in cellular neuroscience · 2020Article
- Immunoglobulins G from Sera of Amyotrophic Lateral Sclerosis Patients Induce Oxidative Stress and Upregulation of Antioxidative System in BV-2 Microglial Cell Line.Frontiers in immunology · 2017Article
- Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction.Nature communications · 2014Article
- Novel molecular biomarkers at the blood-brain barrier in ALS.BioMed research international · 2014Review
- Gephyrin regulates GABAergic and glutamatergic synaptic transmission in hippocampal cell cultures.The Journal of biological chemistry · 2011Article
- Block and allosteric modulation of GABAergic currents by oenanthotoxin in rat cultured hippocampal neurons.British journal of pharmacology · 2010Article
- High affinity carnitine transporters from OCTN family in neural cells.Neurochemical research · 2010Article
- Polyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicus.Journal of natural products · 2009Article
- Molecular substrates mediating lanthanide-evoked neurotransmitter release in central synapses.Journal of neurophysiology · 2008Article
- Flurazepam effect on GABAergic currents depends on extracellular pH.British journal of pharmacology · 2008Article
- Gephyrin selective intrabodies as a new strategy for studying inhibitory receptor clustering.Journal of molecular neuroscience : MN · 2008Article
- Erythropoietin affects GABAergic transmission in hippocampal neurons in vitro.Cellular & molecular biology letters · 2008Article
- GABA transient sets the susceptibility of mIPSCs to modulation by benzodiazepine receptor agonists in rat hippocampal neurons.The Journal of physiology · 2007Article
- Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function.The EMBO journal · 2007Article
- Interaction between cyclodextrin and neuronal membrane results in modulation of GABA(A) receptor conformational transitions.British journal of pharmacology · 2006Article
- Calcium signaling pathways mediating synaptic potentiation triggered by amyotrophic lateral sclerosis IgG in motor nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Article
- Modulation of GABA(A) receptors by hydrogen ions reveals synaptic GABA transient and a crucial role of the desensitization process.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. The whole-cell configuration of the patch-clamp technique was used to study the effects of immunoglobulins (IgGs) from patients affected by amyotrophic lateral sclerosis (ALS) on spontaneous glutamatergic currents in rat hippocampal cells in culture. 2. Focal application of ALS IgGs (100 micrograms ml-1) to hippocampal cells induced a rise in frequency but not in amplitude of spontaneous excitatory postsynaptic currents (SEPSC) which outlasted the period of IgG application. The mean frequency ratio (ALS over control) was 3.2 +/- 0.6 (n = 19). No changes in frequency or amplitude of SEPSCs were observed after treatment with IgGs obtained from healthy donors (n = 5) or from patients with Alzheimer's disease (n = 4). 3. ALS IgGs also increased the frequency (by a factor of 2.0 +/- 0.3) but not the amplitude of miniature excitatory postsynaptic currents (mEPSC) recorded in the presence of TTX (n = 19). A rise in frequency of mEPSC was also seen in cells superfused with a calcium-free solution (n = 4). 4. In the presence of TTX, ALS IgGs did not modify the amplitude or the shape of currents evoked by AMPA (100 microM), recorded at a holding potential of -50 mV. 5. It is concluded that ALS IgGs enhance both SEPSCs and mEPSCs through a presynaptic type of action. The excessive release of glutamate from nerve endings may be the cause of motoneurone death in ALS patients.
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