ArticleThe Journal of physiology1997
Stimulation-induced changes in [Ca2+] in lizard motor nerve terminals.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Monitoring presynaptic calcium dynamics with membrane-impermeant fluorescent indicators in motor nerve endings.Biophysical reviews · 2025Review
- Stimulation-induced Ca(2+) influx at nodes of Ranvier in mouse peripheral motor axons.The Journal of physiology · 2016Article
- Estimation of presynaptic calcium currents and endogenous calcium buffers at the frog neuromuscular junction with two different calcium fluorescent dyes.Frontiers in synaptic neuroscience · 2014Article
- Immunohistological and electrophysiological evidence that N-acetylaspartylglutamate is a co-transmitter at the vertebrate neuromuscular junction.The European journal of neuroscience · 2013Article
- Dicalcin inhibits fertilization through its binding to a glycoprotein in the egg envelope in Xenopus laevis.The Journal of biological chemistry · 2010Article
- Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Stimulation-induced changes in NADH fluorescence and mitochondrial membrane potential in lizard motor nerve terminals.The Journal of physiology · 2007Article
- Ca2+ dynamics along identified synaptic terminals in Drosophila larvae.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Functional compensation of P/Q by N-type channels blocks short-term plasticity at the calyx of Held presynaptic terminal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Spatial Distribution of Calcium Entry Evoked by Single Action Potentials within the Presynaptic Active Zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Mitochondria and release at hippocampal synapses.Pflugers Archiv : European journal of physiology · 2003Article
- Mitochondrial Ca2+ uptake prevents desynchronization of quantal release and minimizes depletion during repetitive stimulation of mouse motor nerve terminals.The Journal of physiology · 2003Article
- Stimulation-evoked increases in cytosolic [Ca(2+)] in mouse motor nerve terminals are limited by mitochondrial uptake and are temperature-dependent.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Action potential-evoked Ca2+ signals and calcium channels in axons of developing rat cerebellar interneurones.The Journal of physiology · 2000Article
- Functional coupling of Ca(2+) channels to ryanodine receptors at presynaptic terminals. Amplification of exocytosis and plasticity.The Journal of general physiology · 2000Article
- Modulation by K+ channels of action potential-evoked intracellular Ca2+ concentration rises in rat cerebellar basket cell axons.The Journal of physiology · 1999Article
- Measurement of action potential-induced presynaptic calcium domains at a cultured neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Mitochondrial clearance of cytosolic Ca(2+) in stimulated lizard motor nerve terminals proceeds without progressive elevation of mitochondrial matrix [Ca(2+)].The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Relationship between presynaptic calcium transients and postsynaptic currents at single gamma-aminobutyric acid (GABA)ergic boutons.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Facilitation of presynaptic calcium currents in the rat brainstem.The Journal of physiology · 1998Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
1. Motor axons were injected ionophoretically with one of five Ca(2+)-sensitive dyes (fluo-3, Calcium Green-2, Calcium Green-5N, fluo-3FF and Oregon Green BAPTA-5N). Changes in fluorescence (delta F/Frest) within motor terminal boutons following a single action potential and brief stimulus trains were monitored with high temporal resolution using a confocal microscope. 2. Stimulation-induced increases in delta F/Frest were confined primarily to boutons, with roughly uniform increases in all the boutons of a terminal. The increase in delta F/Frest began prior to, and decayed more slowly than, the endplate potential (EPP) recorded in the underlying muscle fibre. delta F/Frest was graded with bath [Ca2+]. Both delta F/Frest and the EPP were reduced, but not eliminated, by omega-conotoxin GVIA (5-10 microM). 3. For dyes with lower affinity for Ca2+ (e.g. Oregon Green BAPTA-5N, Kd approximately 60 microM) stimulation-induced increases in delta F/Frest were measured in the presence of the K+ channel blocker 3,4-diaminopyridine (3,4-DAP, 100 microM). During brief stimulus trains (4 at 50 Hz) in 3,4-DAP, the EPP exhibited profound depression, but the fluorescence increase associated with each stimulus showed little decrement, suggesting that depression was not mediated by a reduction in Ca2+ entry. 4. For dyes with a higher affinity for Ca2+ (e.g. fluo-3, Kd approximately 0.5-1 microM) stimulation-induced increases in delta F/Frest could also be measured in normal physiological saline. Increases in delta F/Frest were much greater with 3,4-DAP present, but the amplitude decreased with successive stimuli due to partial dye saturation. 5. Calculations suggested that following a single action potential the average [Ca2+] within a bouton increased by up to 150 nM in normal saline and 940 nM in 3,4-DAP. With low affinity dyes the delta F/Frest measured near the membrane had a higher peak amplitude and a faster early decay than that measured in the centre of the bouton, suggesting that substantial spatial [Ca2+] gradients exist within boutons for at least 15 ms following stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.