ArticleMolecular pathology : MP1997
Mature osteoblasts in human non-union fractures express collagen type III.
Article in Molecular pathology : MP, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Time to consider fracture nonunion an orphan disease? An update into pathophysiology, epidemiology and therapeutic solutions.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- The effects of cephalexin on fracture healing in a rat femur fracture model.Joint diseases and related surgery · 2023Article
- PTH-Induced Bone Regeneration and Vascular Modulation Are Both Dependent on Endothelial Signaling.Cells · 2022Article
- Article
- Type III collagen modulates fracture callus bone formation and early remodeling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Biological and molecular profile of fracture non-union tissue: current insights.Journal of cellular and molecular medicine · 2015Review
- Recent advances in the use of serological bone formation markers to monitor callus development and fracture healing.Critical reviews in eukaryotic gene expression · 2010Review
- [Osteoblasts : cellular and molecular regulatory mechanisms in fracture healing].Der Orthopade · 2009Article
- Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2009Article
- Ischemia leads to delayed union during fracture healing: a mouse model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2007Article
- Expression of the gene encoding the matrix gla protein by mature osteoblasts in human fracture non-unions.Molecular pathology : MP · 1999Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsHigh levels of collagen type III are biochemically detectable in biopsies of non-uniting fractures, and in the serum of patients suffering from this condition. The aim of this study was to determine whether the expression of collagen type III was limited to fibrous tissue in non-unions, or whether some was present in bone.
methodsBiopsies from normally healing human fractures and non-unions were examined using in situ hybridisation and immunohistochemistry.
resultsThe mesenchymal cell population, which includes fibroblast and osteoblast precursors, expressed mRNA for collagen type III. However, mature osteoblasts on the surface of woven bone varied profoundly between normally healing fractures (in which they were negative or occasionally weakly positive) and non-unions (in which they were strongly positive). Areas of woven bone that had osteoblasts positive for collagen type III mRNA also immunostained positively for the protein.
conclusionsThis study shows that non-union fracture callus osteoblasts on the surfaces of woven bone exhibit an unusual phenotype: they express collagen type III, a molecule characteristic of an earlier stage of osteoblast differentiation, which is not expressed by osteoblasts on woven bone surfaces of bone that develops normally. This finding may be useful in developing an early clinical test for impending non-union.
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