ReviewMolecular pathology : MP1997
Role of platelet adhesion in homeostasis and immunopathology.
Review in Molecular pathology : MP, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis.Biomedicines · 2023Article
- Pathophysiology of Cerebral Malaria: Implications of MSCs as A Regenerative Medicinal Tool.Bioengineering (Basel, Switzerland) · 2022Review
- Platelets as Key Factors in Inflammation: Focus on CD40L/CD40.Frontiers in immunology · 2022Review
- Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease.PloS one · 2019Article
- Platelet Inflammatory Response to Stress.Frontiers in immunology · 2019Review
- cAMP and cGMP Play an Essential Role in Galvanotaxis of Cell Fragments.Journal of cellular physiology · 2016Article
- Spontaneous Subdural Haemorrhage: A Rare Association with Plasmodium Vivax Malaria.Journal of clinical and diagnostic research : JCDR · 2016Article
- Commentary.Journal of neurosciences in rural practice · 2014Article
- Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria.PloS one · 2013Article
- Endocytosis and intracellular processing of platelet microparticles by brain endothelial cells.Journal of cellular and molecular medicine · 2012Article
- Platelets present antigen in the context of MHC class I.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries.Intensive care medicine · 2010Article
- Cloning, expression, and hemostatic activities of a disintegrin, r-mojastin 1, from the mohave rattlesnake (Crotalus scutulatus scutulatus).Thrombosis research · 2010Article
- Cerebral malaria: insights from host-parasite protein-protein interactions.Malaria journal · 2010Article
- Potential Benefits of Peroxynitrite.The open pharmacology journal · 2008Article
- Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment.The American journal of pathology · 2004Article
- Studies on biochemical changes with special reference to oxidant and antioxidants in malaria patients.Indian journal of clinical biochemistry : IJCB · 2003Article
- Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria.Infection and immunity · 2002Article
- Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans.Clinical microbiology reviews · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various molecules expressed on the surface of platelets have been shown to mediate the protective or deleterious role of these cells in immuno-inflammatory mechanisms. Increasing evidence points to the involvement of the cell adhesion molecules, gpIIb-IIIa, P-selectin, CD31, LFA-1, and CD36 in the interaction between platelets and endothelial cells as well as other cell types. The possible role of these molecules in the ability of platelets to support endothelium and to protect against tumour necrosis factor mediated cytolysis or parasitic invasion are reviewed. The involvement of platelets as effectors of tissue damage in cerebral malaria, lipopolysaccharide induced pathology, and pulmonary fibrosis is also discussed. This has then been extended to include the intercellular mechanisms underpinning their pathogenic role in metastasis, transplant rejection, stroke, brain hypoxia, and related conditions. A better understanding of the complex regulation and hierarchical organisation of these various platelet adhesion molecules may prove useful in the development of new approaches to the treatment of such diseases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.