ArticleThe Journal of general physiology1997
Sodium and calcium inward currents in freshly dissociated smooth myocytes of rat uterus.
Article in The Journal of general physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Sodium channels and transporters in the myometrium.Current opinion in physiology · 2020Article
- Electro-Mechanical Ionic Channel Modeling for Uterine Contractions and Oxytocin Effect during Pregnancy.Sensors (Basel, Switzerland) · 2019Article
- Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles.Advances in experimental medicine and biology · 2019Review
- A computational model of excitation and contraction in uterine myocytes from the pregnant rat.Scientific reports · 2018Article
- The role of cellular coupling in the spontaneous generation of electrical activity in uterine tissue.PloS one · 2015Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Computational modeling of inhibition of voltage-gated Ca channels: identification of different effects on uterine and cardiac action potentials.Frontiers in physiology · 2014Article
- Article
- Myometrial interstitial cells and the coordination of myometrial contractility.Journal of cellular and molecular medicine · 2009Review
- Mathematical modeling of electrical activity of uterine muscle cells.Medical & biological engineering & computing · 2009Article
- Potassium channels and uterine function.Seminars in cell & developmental biology · 2007Review
- Towards understanding the myometrial physiome: approaches for the construction of a virtual physiological uterus.BMC pregnancy and childbirth · 2007Review
- Depletion of membrane cholesterol eliminates the Ca2+-activated component of outward potassium current and decreases membrane capacitance in rat uterine myocytes.The Journal of physiology · 2007Article
- Effects of female steroid hormones on A-type K+ currents in murine colon.The Journal of physiology · 2006Article
- Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.Pflugers Archiv : European journal of physiology · 2005Article
- Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes.The Journal of physiology · 2005Article
- Descending vasa recta pericytes express voltage operated Na+ conductance in the rat.The Journal of physiology · 2005Article
- L-type Ca2+ channel and Ca2+-permeable nonselective cation channel as a Ca2+ conducting pathway in myocytes isolated from the cricket lateral oviduct.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2004Article
- Calcium antagonistic properties of the cyclooxygenase-2 inhibitor nimesulide in human myometrial myocytes.British journal of pharmacology · 1999Article
- Potassium currents in freshly dissociated uterine myocytes from nonpregnant and late-pregnant rats.The Journal of general physiology · 1998Article
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3 authors at 1 institution in 1 country.
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Abstract
Freshly dissociated myocytes from nonpregnant, pregnant, and postpartum rat uteri have been studied with the tight-seal patch-clamp method. The inward current contains both INa and ICa that are vastly different from those in tissue-cultured material. INa is abolished by Na+-free medium and by 1 microM tetrodotoxin. It first appears at approximately -40 mV, reaches maximum at 0 mV, and reverses at 84 mV. It activates with a voltage-dependent tau of 0.2 ms at 20 mV, and inactivates as a single exponential with a tau of 0. 4 ms. Na+ conductance is half activated at -21.5 mV, and half inactivated at -59 mV. INa reactivates with a tau of 20 ms. ICa is abolished by Ca2+-free medium, Co2+ (5 mM), or nisoldipine (2 microM), and enhanced in 30 mM Ca2+, Ba2+, or BAY-K 8644. It first appears at approximately -30 mV and reaches maximum at +10 mV. It activates with a voltage-dependent tau of 1.5 ms at 20 mV, and inactivates in two exponential phases, with tau's of 33 and 133 ms. Ca2+ conductance is half activated at -7.4 mV, and half inactivated at -34 mV. ICa reactivates with tau's of 27 and 374 ms. INa and ICa are seen in myocytes from nonpregnant estrus uteri and throughout pregnancy, exhibiting complex changes. The ratio of densities of peak INa/ICa changes from 0.5 in the nonpregnant state to 1.6 at term. The enhanced role of INa, with faster kinetics, allows more frequent repetitive spike discharges to facilitate simultaneous excitation of the parturient uterus. In postpartum, both currents decrease markedly, with INa vanishing from most myocytes. Estrogen-enhanced genomic influences may account for the emergence of INa, and increased densities of INa and ICa as pregnancy progresses. Other influences may regulate varied channel expression at different stages of pregnancy.
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