ArticleThe Journal of experimental medicine1997
Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 270 citations in OpenAlex.
- A prevalent disease-associated SNP in the humanNAR molecular medicine · 2026Article
- A human NK cell progenitor that originates in the thymus and generates KIRScience advances · 2025Article
- T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025Review
- Speed and navigation control of thymocyte development by the fetal T-cell gene regulatory network.Immunological reviews · 2023Review
- The divergence between T cell and innate lymphoid cell fates controlled by E and Id proteins.Frontiers in immunology · 2022Review
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- EfficientFrontiers in immunology · 2021Article
- Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family.Frontiers in immunology · 2021Review
- Review
- Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection.Immunological reviews · 2018Review
- A Jurkat 76 based triple parameter reporter system to evaluate TCR functions and adoptive T cell strategies.Oncotarget · 2018Article
- Transcriptional and post-transcriptional regulation of NK cell development and function.Clinical immunology (Orlando, Fla.) · 2017Review
- Human CD5Frontiers in immunology · 2017Article
- Immunoregulation by members of the TGFβ superfamily.Nature reviews. Immunology · 2016Review
- Development and maturation of natural killer cells.Current opinion in immunology · 2016Review
- Transcriptional regulation of innate lymphoid cell fate.Nature reviews. Immunology · 2015Review
- Transcription factors and target genes of pre-TCR signaling.Cellular and molecular life sciences : CMLS · 2015Review
- Transcriptional and epigenetic networks of helper T and innate lymphoid cells.Immunological reviews · 2014Review
- IL-12 directs further maturation of ex vivo differentiated NK cells with improved therapeutic potential.PloS one · 2014Article
- Multi-cistronic vector encoding optimized safety switch for adoptive therapy with T-cell receptor-modified T cells.Gene therapy · 2013Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipotential T/natural killer (NK) progenitor cells are present in the human thymus. Despite their bipotential capacity, these progenitors develop predominantly to T cells in the thymus. The mechanisms controlling this developmental choice are unknown. Here we present evidence that a member(s) of the family of basic helix loop helix (bHLH) transcription factors determines lineage specification of NK/T cell progenitors. The natural dominant negative HLH factor Id3, which blocks transcriptional activity of a number of known bHLH factors, was expressed in CD34+ progenitor cells by retrovirus-mediated gene transfer. Constitutive expression of Id3 completely blocks development of CD34+ cells into T cells in a fetal thymic organ culture (FTOC). In contrast, development into NK cells in an FTOC is enhanced. Thus, the activity of a bHLH transcription factor is necessary for T lineage differentiation of bipotential precursors, in the absence of which a default pathway leading to NK cell development is chosen. Our results identify a molecular switch for lineage specification in early lymphoid precursors of humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.