ArticleAmerican journal of human genetics1997
Allele-sharing models: LOD scores and accurate linkage tests.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 393 papers, 4 of them syntheses that pooled it.
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Who cites it
393 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder.Human genetics · 2026Pooled it
- Meta-analysis of repository data: impact of data regularization on NIMH schizophrenia linkage results.PloS one · 2014Pooled it
- Meta-analysis of genome-wide linkage studies in celiac disease.Human heredity · 2009Pooled it
- Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium.Human heredity · 2008Pooled it
- Linkage Analysis in Autoimmune Addison's Disease: NFATC1 as a Potential Novel Susceptibility Locus.PloS one · 2015Trial
- Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans.Human genetics · 2013Trial
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- Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families.bioRxiv : the preprint server for biology · 2025Article
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- The conserved ASTN2/BRINP1 locus at 9q33.1-33.2 is associated with major psychiatric disorders in a large pedigree from Southern Spain.Scientific reports · 2021Article
- Evidence for gene-smoking interactions for hearing loss and deafness in Japanese American families.Hearing research · 2020Article
- Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice.Human molecular genetics · 2019Article
- A Rare Variant Nonparametric Linkage Method for Nuclear and Extended Pedigrees with Application to Late-Onset Alzheimer Disease via WGS Data.American journal of human genetics · 2019Article
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- Panic disorders: The role of genetics and epigenetics.AIMS genetics · 2018Review
- Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux.Scientific reports · 2017Article
- Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance.Nature communications · 2017Article
333 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
Abstract
Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of likelihood ratios and LOD scores and has been implemented by a simple modification of existing software. Most important, accurate linkage tests can be performed. Using an example, we show that some previously suggested approaches to handling less than perfectly informative data can be unacceptably conservative. Situations in which this model may not perform well are discussed, and an alternative model that requires additional computations is suggested.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.