ArticleMolecular and cellular biology1997
A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products.Aging and disease · 2024Review
- MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies.Journal of hematology & oncology · 2021Review
- Mitochondrial mitophagic mechanisms of myocardial matrix metabolism and remodelling.Archives of physiology and biochemistry · 2012Review
- Myc down-regulation affects cyclin D1/cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line.Cell proliferation · 2009Article
- Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization.Oncogene · 2006Article
- Okadaic acid stimulates caspase-like activities and induces apoptosis of cultured rat mesangial cells.Molecular and cellular biochemistry · 2004Article
- c-MYC apoptotic function is mediated by NRF-1 target genes.Genes & development · 2003Article
- Article
- Deregulated c-Myc prematurely recruits both Type I and II CD95/Fas apoptotic pathways associated with terminal myeloid differentiation.Oncogene · 2002Article
- Involvement of p38 in apoptosis-associated membrane blebbing and nuclear condensation.Molecular biology of the cell · 2001Article
- The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program.Oncogene · 2000Article
- p53-independent apoptosis associated with c-Myc-mediated block in myeloid cell differentiation.Oncogene · 2000Article
- Caspases and mitochondria in c-Myc-induced apoptosis: identification of ATM as a new target of caspases.Oncogene · 2000Article
- The roles of caspase-3 and bcl-2 in chemically-induced apoptosis but not necrosis of renal epithelial cells.Oncogene · 1999Article
- Implication of c-Myc in apoptosis induced by the retinoid CD437 in human lung carcinoma cells.Oncogene · 1999Article
- Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts.Oncogene · 1999Article
- c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release.Genes & development · 1999Article
- Mechanisms of apoptosis by c-Myc.Oncogene · 1999Review
- Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells.Oncogene · 1999Article
- Induction of programmed cell death by parvovirus H-1 in U937 cells: connection with the tumor necrosis factor alpha signalling pathway.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon activation, cell surface death receptors, Fas/APO-1/CD95 and tumor necrosis factor receptor-1 (TNFR-1), are attached to cytosolic adaptor proteins, which in turn recruit caspase-8 (MACH/FLICE/Mch5) to activate the interleukin-1 beta-converting enzyme (ICE)/CED-3 family protease (caspase) cascade. However, it remains unknown whether these apoptotic proteases are generally involved in apoptosis triggered by other stimuli such as Myc and p53. In this study, we provide lines of evidence that a death protease cascade consisting of caspases and serine proteases plays an essential role in Myc-mediated apoptosis. When Rat-1 fibroblasts stably expressing either s-Myc or c-Myc were induced to undergo apoptosis by serum deprivation, a caspase-3 (CPP32)-like protease activity that cleaves a specific peptide substrate, Ac-DEVD-MCA, appeared in the cell lysates. Induction of s-Myc- and c-Myc-mediated apoptotic cell death was effectively prevented by caspase inhibitors such as Z-Asp-CH2-DCB and Ac-DEVD-CHO. Furthermore, exposing the cells to a serine protease inhibitor, 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF), also significantly inhibited s-Myc- and c-Myc-mediated apoptosis and the appearance of the caspase-3-like protease activity in vivo. However, AEBSF did not directly inhibit caspase-3-like protease activity in the apoptotic cell lysates in vitro. Together, these results indicate that caspase-3-like proteases play a critical role in both s-Myc- and c-Myc-mediated apoptosis and that caspase-3-like proteases function downstream of the AEBSF-sensitive step in the signaling pathway of Myc-mediated apoptosis.
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