ArticleMolecular and cellular biology1997
Tissue-specific splicing and functions of the Drosophila transcription factor Grainyhead.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 86 citations in OpenAlex.
- Pioneer-factor activity requires stable chromatin occupancy mediated by both sequence-specific binding and disordered protein domains.Science advances · 2026Article
- Altering cell size asymmetry inbioRxiv : the preprint server for biology · 2025Article
- Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation.Cell death discovery · 2025Article
- Exploring the reciprocity between pioneer factors and development.Development (Cambridge, England) · 2024Review
- Article
- Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts.Neural development · 2022Article
- Post-transcriptional control of cellular differentiation by the RNA exosome complex.Nucleic acids research · 2020Review
- Establishment of chromatin accessibility by the conserved transcription factor Grainy head is developmentally regulated.Development (Cambridge, England) · 2020Article
- Spotlight on the Granules (Grainyhead-Like Proteins) - From an Evolutionary Conserved Controller of Epithelial Trait to Pioneering the Chromatin Landscape.Frontiers in molecular biosciences · 2020Review
- Disordered Expression ofInternational journal of molecular sciences · 2019Article
- The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila.Developmental biology · 2019Article
- Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues.Developmental biology · 2018Article
- Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.Scientific reports · 2017Article
- Genome-wide identification of Grainy head targets inDevelopment (Cambridge, England) · 2017Article
- Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development.Genetics · 2017Article
- A Hox Transcription Factor Collective Binds a Highly Conserved Distal-less cis-Regulatory Module to Generate Robust Transcriptional Outcomes.PLoS genetics · 2016Article
- Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis.Developmental biology · 2012Article
- Regulated functional alternative splicing in Drosophila.Nucleic acids research · 2012Review
- Immune response in the barrier epithelia: lessons from the fruit fly Drosophila melanogaster.Journal of innate immunity · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grainyhead belongs to a recently identified group of transcription factors which share a 250-amino-acid domain required for binding to DNA and a carboxy-terminal dimerization domain. The activities of Grainyhead and other members of the family appear to be modulated so that they can participate in different developmental processes. We have examined the structure and function of mRNAs from the Drosophila grainyhead gene and demonstrated that alternate splicing is responsible for generating a neuroblast-specific isoform of the protein. A mutation which abolishes this isoform results in pupal and adult lethality. Reporter genes containing different Grainyhead binding sites exhibit tissue-specific patterns of expression that correlate with the Grainyhead isoforms, suggesting that the alternate splicing serves to alter the repertoire of target genes controlled in the neuroblasts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.