ArticleMolecular and cellular biology1997
Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- EED-associated overgrowth in a second male patient.Journal of human genetics · 2016Article
- PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Epigenetic repressor-like genes are differentially regulated during grapevine (Vitis vinifera L.) development.Plant cell reports · 2011Article
- Sexual and apomictic seed formation in Hieracium requires the plant polycomb-group gene FERTILIZATION INDEPENDENT ENDOSPERM.The Plant cell · 2008Article
- Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED.Virology journal · 2008Article
- Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation.Journal of molecular biology · 2007Article
- Human Polycomb group EED protein negatively affects HIV-1 assembly and release.Retrovirology · 2007Article
- The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27.Molecular and cellular biology · 2007Article
- Alternative ESC and ESC-like subunits of a polycomb group histone methyltransferase complex are differentially deployed during Drosophila development.Molecular and cellular biology · 2006Article
- Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes.Molecular and cellular biology · 2005Article
- The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1.Journal of virology · 2003Article
- Genomic imprinting and endosperm development in flowering plants.Molecular biotechnology · 2003Review
- The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor.Nucleic acids research · 2003Article
- Duplicated fie genes in maize: expression pattern and imprinting suggest distinct functions.The Plant cell · 2003Article
- Sequence relationships, conserved domains, and expression patterns for maize homologs of the polycomb group genes E(z), esc, and E(Pc).Plant physiology · 2002Article
- The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas.Oncogene · 2002Article
- Long-range repression by multiple polycomb group (PcG) proteins targeted by fusion to a defined DNA-binding domain in Drosophila.Genetics · 2001Article
- Mutations in the FIE and MEA genes that encode interacting polycomb proteins cause parent-of-origin effects on seed development by distinct mechanisms.The Plant cell · 2000Article
- Interaction of the U3-55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3-55k.Nucleic acids research · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila extra sex combs (esc) protein, a member of the Polycomb group (PcG), is a transcriptional repressor of homeotic genes. Genetic studies have shown that esc protein is required in early embryos at about the time that other PcG proteins become engaged in homeotic gene repression. The esc protein consists primarily of multiple copies of the WD repeat, a motif that has been implicated in protein-protein interaction. To further investigate the domain organization of esc protein, we have isolated and characterized esc homologs from divergent insect species. We report that esc protein is highly conserved in housefly (72% identical to Drosophila esc), butterfly (55% identical), and grasshopper (56% identical). We show that the butterfly homolog provides esc function in Drosophila, indicating that the sequence similarities reflect functional conservation. Homology modeling using the crystal structure of another WD repeat protein, the G-protein beta-subunit, predicts that esc protein adopts a beta-propeller structure. The sequence comparisons and modeling suggest that there are seven WD repeats in esc protein which together form a seven-bladed beta-propeller. We locate the conserved regions in esc protein with respect to this predicted structure. Site-directed mutagenesis of specific loops, predicted to extend from the propeller surface, identifies conserved parts of esc protein required for function in vivo. We suggest that these regions might mediate physical interaction with esc partner proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.