ArticleMolecular and cellular biology1997
Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in Schistosoma mansoni.Nucleic acids research · 2025Article
- Profiling of the transcriptional response to all-trans retinoic acid in breast cancer cells reveals RARE-independent mechanisms of gene expression.Scientific reports · 2017Article
- Implication of retinoic acid receptor selective signaling in myogenic differentiation.Scientific reports · 2016Article
- Enhancing myogenic differentiation of pluripotent stem cells with small molecule inducers.Cell & bioscience · 2013Article
- Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity.Genome biology · 2012Article
- Identification of natural human glucocorticoid receptor (hGR) mutations or polymorphisms and their functional consequences at the hormone-receptor interaction level.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties.Molecular and cellular biology · 2003Article
- A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription.The EMBO journal · 2003Article
- DNA methylation and breast carcinogenesis.Oncogene · 2002Review
- Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation.EMBO reports · 2002Article
- Chromosomal integration of retinoic acid response elements prevents cooperative transcriptional activation by retinoic acid receptor and retinoid X receptor.Molecular and cellular biology · 2002Article
- Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin.Molecular biology of the cell · 2001Article
- The cyclin B1 gene is actively transcribed during mitosis in HeLa cells.EMBO reports · 2001Article
- Review
- Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer.The American journal of pathology · 2001Article
- Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX.Molecular and cellular biology · 2000Article
- Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells.Oncogene · 2000Article
- Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo.The EMBO journal · 1998Article
- A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription of the retinoic acid receptor beta2 (RARbeta2) gene is induced by retinoic acid (RA) in mouse P19 embryonal carcinoma (EC) cells. Here we studied RA-induced chromatin structure alterations in the endogenous RARbeta2 promoter and in an integrated, multicopy RARbeta2 promoter in EC cells. RA markedly increased restriction site accessibility within the promoter, including a site near the RA responsive element (RARE) to which the nuclear receptor retinoid X receptor (RXR)-RAR heterodimer binds. These changes coincided with RA-induced alterations in the DNase I hypersensitivity pattern in and around the promoter. These changes became undetectable upon removal of RA, which coincided with the extinction of transcription. Analyses with receptor-selective ligands and an antagonist showed that increase in restriction site accessibility correlates with transcriptional activation, which parallels the RA-induced in vivo footprint of the promoter. Despite these changes, the micrococcal nuclease digestion profile of this promoter was not altered by RA. These results indicate that concurrent with the binding of the RXR-RAR heterodimer to the RARE, the local chromatin structure undergoes dynamic, reversible changes in and around the promoter without globally affecting the nucleosomal organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.