ArticleJournal of virology1997
Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- c-FLIP as a master regulator of immune homeostasis and disease mechanisms.Cell death & disease · 2026Review
- Assessment of replication of bovine herpesvirus type 4 in human glioblastoma and breast cancer cells as a potential oncolytic virus.Virus genes · 2021Article
- Unravelling the first key steps in equine herpesvirus type 5 (EHV5) pathogenesis using ex vivo and in vitro equine models.Veterinary research · 2019Article
- Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance.Scientific reports · 2012Article
- The interaction between human papillomavirus type 16 and FADD is mediated by a novel E6 binding domain.Journal of virology · 2008Article
- Cellular binding partners of the human papillomavirus E6 protein.Archives of virology · 2008Review
- Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis.Cell death and differentiation · 2006Article
- Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis.Apoptosis : an international journal on programmed cell death · 2005Article
- Article
- Langat flavivirus protease NS3 binds caspase-8 and induces apoptosis.Journal of virology · 2002Article
- Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function.Journal of virology · 2002Article
- Poliovirus protein 3A inhibits tumor necrosis factor (TNF)-induced apoptosis by eliminating the TNF receptor from the cell surface.Journal of virology · 2001Article
- Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection.Oncogene · 2001Article
- Viruses and apoptosis.International journal of experimental pathology · 2001Review
- Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and identification of an origin of DNA replication.Journal of virology · 2001Article
- Herpesvirus saimiri vFLIP provides an antiapoptotic function but is not essential for viral replication, transformation, or pathogenicity.Journal of virology · 2000Article
- Mechanisms of apoptosis.The American journal of pathology · 2000Article
- Reovirus-induced apoptosis is mediated by TRAIL.Journal of virology · 2000Article
- Antiapoptotic activity of the herpesvirus saimiri-encoded Bcl-2 homolog: stabilization of mitochondria and inhibition of caspase-3-like activity.Journal of virology · 1998Article
- Diverse mechanisms evolved by DNA viruses to inhibit early host defenses.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fas- and tumor necrosis factor receptor 1 (TNFR1)-induced apoptosis is mediated by the interaction of FADD with caspase-8. Here, we report that the bovine herpesvirus 4 (BHV4) BORFE2 gene encodes a protein that inhibits Fas- and TNFR1-induced apoptosis and contains death effector domains (DEDs). Using the yeast two-hybrid system, we found that the BORFE2 protein interacts with the prodomain of caspase-8. Furthermore, we show that BHV4 BORFE2 is a member of a family of DED-containing proteins that includes other gamma-2 herpesviruses, such as Kaposi's sarcoma-associated herpesvirus and herpesvirus saimiri.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.