ArticleProceedings of the National Academy of Sciences of the United States of America1997
Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Phosphoproteomic profiling reveals reversal of dysregulated kinase signaling by nitric oxide inhibition in the Shank3 mouse model of autism.Scientific reports · 2026Article
- Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons.Frontiers in molecular neuroscience · 2023Review
- SIV-Mediated Synaptic Dysfunction Is Associated with an Increase in Synapsin Site 1 Phosphorylation and Impaired PP2A Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.The EMBO journal · 2018Article
- Local substrates of non-receptor tyrosine kinases at synaptic sites in neurons.Sheng li xue bao : [Acta physiologica Sinica] · 2017Review
- A Novel Topology of Proline-rich Transmembrane Protein 2 (PRRT2): HINTS FOR AN INTRACELLULAR FUNCTION AT THE SYNAPSE.The Journal of biological chemistry · 2016Article
- Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin.The Journal of cell biology · 2013Article
- Article
- Regulation of SRC family kinases in human cancers.Journal of signal transduction · 2011Article
- The role of synapsins in neuronal development.Cellular and molecular life sciences : CMLS · 2010Review
- Cytoplasmic prion protein induces forebrain neurotoxicity.Biochimica et biophysica acta · 2009Article
- Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors.Nature neuroscience · 2007Article
- Colocalization of synapsin and actin during synaptic vesicle recycling.The Journal of cell biology · 2003Article
- Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Review
- Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity.The EMBO journal · 2000Article
- Tyrosine phosphorylation regulates rapid endocytosis in adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Synapsin I is a synaptic vesicle-associated phosphoprotein that has been implicated in the formation of presynaptic specializations and in the regulation of neurotransmitter release. The nonreceptor tyrosine kinase c-Src is enriched on synaptic vesicles, where it accounts for most of the vesicle-associated tyrosine kinase activity. Using overlay, affinity chromatography, and coprecipitation assays, we have now shown that synapsin I is the major binding protein for the Src homology 3 (SH3) domain of c-Src in highly purified synaptic vesicle preparations. The interaction was mediated by the proline-rich domain D of synapsin I and was not significantly affected by stoichiometric phosphorylation of synapsin I at any of the known regulatory sites. The interaction of purified c-Src and synapsin I resulted in a severalfold stimulation of tyrosine kinase activity and was antagonized by the purified c-Src-SH3 domain. Depletion of synapsin I from purified synaptic vesicles resulted in a decrease of endogenous tyrosine kinase activity. Portions of the total cellular pools of synapsin I and Src were coprecipitated from detergent extracts of rat brain synaptosomal fractions using antibodies to either protein species. The interaction between synapsin I and c-Src, as well as the synapsin I-induced stimulation of tyrosine kinase activity, may be physiologically important in signal transduction and in the modulation of the function of axon terminals, both during synaptogenesis and at mature synapses.
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