ArticleProceedings of the National Academy of Sciences of the United States of America1997
A gene spans the pseudoautosomal boundary in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- Comparative sequence analysis of the mouse pseudoautosomal region from three inbred strains reveals it to be the most rapidly evolving 'chromosome'.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026Article
- Highly polymorphic copy number variation in a segmental duplication in the mouse pseudoautosomal region even within inbred laboratory strains.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026Article
- Trio-binning of a hinny refines the comparative organization of the horse and donkey X chromosomes and reveals novel species-specific features.Scientific reports · 2023Article
- Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.BMC genomics · 2023Article
- Effects of the Sex Chromosome Complement, XX, XO, or XY, on the Transcriptome and Development of Mouse Oocytes During Follicular Growth.Frontiers in genetics · 2021Article
- Review
- Article
- The Location of the Pseudoautosomal Boundary inGenes · 2020Article
- Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.Molecular biology and evolution · 2020Article
- Instability of the Pseudoautosomal Boundary in House Mice.Genetics · 2019Article
- Article
- Is the telomere length associated with neurocognitive disabilities in HIV-1-infected subjects?Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Article
- Article
- A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues.Biology of sex differences · 2016Review
- Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies.Brain structure & function · 2015Article
- A polymorphic pseudoautosomal boundary in the Carica papaya sex chromosomes.Molecular genetics and genomics : MGG · 2015Article
- Effects of Prenatal Testosterone Exposure on Sexually Dimorphic Gene Expression in the Neonatal Mouse Cortex and Hippocampus.Journal of steroids & hormonal science · 2014Article
- Identification of sexually dimorphic genes in the neonatal mouse cortex and hippocampus.Brain research · 2014Article
- A pronounced evolutionary shift of the pseudoautosomal region boundary in house mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The X and Y chromosomes of the mouse, like those of other mammals, are heteromorphic over most of their length, but at the distal ends of the chromosomes is a region of sequence identity, the pseudoautosomal region (PAR), where the chromosomes pair and recombine during male meiosis. The point at which the PAR diverges into X- and Y-specific sequences is called the pseudoautosomal boundary. We have completed a genomic walk from the X-specific Amelogenin gene to the PAR. Analysis of this region revealed that the pseudoautosomal boundary of mice is located within an intron of a transcribed gene that encodes a novel RING finger protein. The first three of the exons of the gene are located on the X chromosome whereas the 3' exons of the gene are located on both X and Y chromosomes. This unusual arrangement may indicate that the gene is in a state of transition from pseudoautosomal to X-unique and provides evidence for a process of attrition of the pseudoautosomal region on the Y chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.