ArticleProceedings of the National Academy of Sciences of the United States of America1997
Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- Clinical and Genetic Characteristics ofJournal of diabetes research · 2021Pooled it
- Paradoxical Maturity-Onset Diabetes of the Young Arising From Loss-of-Function Mutations in ATP-Sensitive Potassium Channels.Diabetes · 2026Article
- Personalized Therapeutics for KAnnual review of pharmacology and toxicology · 2023Review
- Pituitary stalk interruption syndrome and liver cirrhosis associated with diabetes and an inactivatingFrontiers in endocrinology · 2023Review
- PyCreas: a tool for quantification of localization and distribution of endocrine cell types in the islets of Langerhans.Frontiers in endocrinology · 2023Article
- SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism.Diabetologia · 2021Article
- Identification of a compound heterozygous inactivating ABCC8 gene mutation responsible for young-onset diabetes with exome sequencing.Journal of diabetes investigation · 2020Article
- The role of membrane excitability in pancreatic β-cell glucotoxicity.Scientific reports · 2019Article
- Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism.Scientific reports · 2019Article
- Congenital Hyperinsulinism and Evolution to Sulfonylurearesponsive Diabetes Later in Life due to a Novel Homozygous p.L171FJournal of clinical research in pediatric endocrinology · 2019Article
- High-fat-diet-induced remission of diabetes in a subset of KDiabetes, obesity & metabolism · 2018Article
- Nutrient sensing in pancreatic islets: lessons from congenital hyperinsulinism and monogenic diabetes.Annals of the New York Academy of Sciences · 2018Review
- Functional and Metabolomic Consequences of KDiabetes · 2017Article
- Glucose-stimulated single pancreatic islets sustain increased cytosolic ATP levels during initial Ca2+ influx and subsequent Ca2+ oscillations.The Journal of biological chemistry · 2014Article
- Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes.Diabetologia · 2013Article
- The diabetic β-cell: hyperstimulated vs. hyperexcited.Diabetes, obesity & metabolism · 2012Review
- K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.Nature neuroscience · 2012Article
- Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.Diabetologia · 2012Review
- Nateglinide is Effective for Diabetes Mellitus with Reactive Hypoglycemia in a Child with a Compound Heterozygous ABCC8 Mutation.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2012Article
- Measuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle.Journal of molecular and cellular cardiology · 2012Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATP-sensitive K+ (KATP) channels are known to play important roles in various cellular functions, but the direct consequences of disruption of KATP channel function are largely unknown. We have generated transgenic mice expressing a dominant-negative form of the KATP channel subunit Kir6.2 (Kir6.2G132S, substitution of glycine with serine at position 132) in pancreatic beta cells. Kir6.2G132S transgenic mice develop hypoglycemia with hyperinsulinemia in neonates and hyperglycemia with hypoinsulinemia and decreased beta cell population in adults. KATP channel function is found to be impaired in the beta cells of transgenic mice with hyperglycemia. In addition, both resting membrane potential and basal calcium concentrations are shown to be significantly elevated in the beta cells of transgenic mice. We also found a high frequency of apoptotic beta cells before the appearance of hyperglycemia in the transgenic mice, suggesting that the KATP channel might play a significant role in beta cell survival in addition to its role in the regulation of insulin secretion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.