ArticleProceedings of the National Academy of Sciences of the United States of America1997
Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- BTAF1: a key regulator of DNA end resection and predictor of chemotherapy sensitivity in gastric cancer.Cell death and differentiation · 2026Article
- Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.Nucleic acids research · 2012Article
- One small step for Mot1; one giant leap for other Swi2/Snf2 enzymes?Biochimica et biophysica acta · 2011Review
- A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.The EMBO journal · 2010Article
- A proteomics analysis of yeast Mot1p protein-protein associations: insights into mechanism.Molecular & cellular proteomics : MCP · 2008Article
- Yeast two-hybrid map of Arabidopsis TFIID.Plant molecular biology · 2007Article
- Mutational analysis of BTAF1-TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants.Nucleic acids research · 2005Article
- NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein.Molecular and cellular biology · 2004Article
- High-affinity DNA binding by a Mot1p-TBP complex: implications for TAF-independent transcription.The EMBO journal · 2003Article
- The NC2 alpha and beta subunits play different roles in vivo.Genes & development · 2002Article
- Evidence that TAF-TATA box-binding protein interactions are required for activated transcription in mammalian cells.Molecular and cellular biology · 2002Article
- TAF(II)170 interacts with the concave surface of TATA-binding protein to inhibit its DNA binding activity.Molecular and cellular biology · 2001Article
- The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization.The Biochemical journal · 2000Article
- MOT1 can activate basal transcription in vitro by regulating the distribution of TATA binding protein between promoter and nonpromoter sites.Molecular and cellular biology · 1999Article
- The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster.Molecular and cellular biology · 1999Article
- Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis.The EMBO journal · 1998Article
- Molecular genetics of the RNA polymerase II general transcriptional machinery.Microbiology and molecular biology reviews : MMBR · 1998Review
- Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1.Molecular and cellular biology · 1998Article
- A multiplicity of mediators: alternative forms of transcription complexes communicate with transcriptional regulators.Nucleic acids research · 1997Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human transcription factor B-TFIID is comprised of TATA-binding protein (TBP) in complex with one TBP-associated factor (TAF) of 170 kDa. We report the isolation of the cDNA for TAFII170. By cofractionation and coprecipitation experiments, we show that the protein encoded by the cDNA encodes the TAF subunit of B-TFIID. Recombinant TAFII170 has (d)ATPase activity. Inspection of its primary structure reveals a striking homology with genes of other organisms, yeast MOT1, and Drosophila moira, which belongs to the Trithorax group. Both homologs were isolated in genetic screens as global regulators of pol II transcription. This supports our classification of B-TFIID as a pol II transcription factor and suggests that specific TBP-TAF complexes perform distinct functions during development.
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