ArticleProceedings of the National Academy of Sciences of the United States of America1997
Making chemistry selectable by linking it to infectivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 61 citations in OpenAlex.
- Antibody selection using clonal cocultivation ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Phenotype-information-phenotype cycle for deconvolution of combinatorial antibody libraries selected against complex systems.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin.Bioorganic & medicinal chemistry · 2008Article
- Routes to covalent catalysis by reactive selection for nascent protein nucleophiles.Journal of the American Chemical Society · 2007Article
- Identification and characterization of single chain anti-cocaine catalytic antibodies.Journal of molecular biology · 2007Article
- Examination of the new alpha-(2'Z-fluoro)vinyl trigger with lysine decarboxylase: the absolute stereochemistry dictates the reaction course.Journal of the American Chemical Society · 2007Article
- Toward cocaine esterase therapeutics.Journal of the American Chemical Society · 2005Article
- Treating cocaine addiction with viruses.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- A method for the generation of combinatorial antibody libraries using pIX phage display.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Human antibodies against spores of the genus Bacillus: a model study for detection of and protection against anthrax and the bioterrorist threat.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewisx and Lewisx.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Making artificial antibodies: a format for phage display of combinatorial heterodimeric arrays.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- A method for directed evolution and functional cloning of enzymes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The link between recognition and replication is fundamental to the operation of the immune system. In recent years, modeling this process in a format of phage-display combinatorial libraries has afforded a powerful tool for obtaining valuable antibodies. However, the ability to readily select and isolate rare catalysts would expand the scope of library technology. A technique in which phage infection controlled the link between recognition and replication was applied to show that chemistry is a selectable process. An antibody that operated by covalent catalysis to form an acyl intermediate restored phage infectivity and allowed selection from a library in which the catalyst constituted 1 in 10(5) members. Three different selection approaches were examined for their convenience and generality. Incorporating these protocols together with well known affinity labels and mechanism-based inactivators should allow the procurement of a wide range of novel catalytic antibodies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.