Trial reportAnnals of surgery1997
Factors predicting a successful outcome after pharmacologic bowel compensation.
Trial report in Annals of surgery, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Pooled it
- Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial.Annals of surgery · 2005Trial
- Navigating the Prognosis and Functional Recovery of Short Bowel Syndrome: A Mentored Review.Digestive diseases and sciences · 2026Review
- Evaluation of health-related quality of life and performance in intestinal transplant and rehabilitation patients: a cross-sectional study.Annals of surgical treatment and research · 2025Article
- Visceral transplantation in patients with intestinal-failure associated liver disease: Evolving indications, graft selection, and outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Review
- India's first successful intestinal transplant: the road traveled and the lessons learnt.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2014Review
- Novel therapies for the management of short bowel syndrome in children.Pediatric surgery international · 2013Review
- Differential protein expression during colonic adaptation in ultra-short bowel rats.World journal of gastroenterology · 2011Article
- Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3.World journal of gastroenterology · 2009Article
- Advances in short bowel syndrome: an updated review.Pediatric surgery international · 2005Review
- A multidisciplinary approach to the treatment of intestinal failure.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2005Article
- Effect of bowel rehabilitative therapy on structural adaptation of remnant small intestine: animal experiment.World journal of gastroenterology · 2001Article
- Growth hormone stimulates remnant small bowel epithelial cell proliferation.World journal of gastroenterology · 2000Article
- T-cell dysfunction in a patient with short bowel syndrome: report of a case.Surgery today · 1999Article
- An integrated approach to intestinal failure: results of a new program with total parenteral nutrition, bowel rehabilitation, and transplantation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Short bowel syndrome: a review of management options.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe authors determined those factors that predict a successful outcome in patients who receive pharmacologic agents to promote bowel absorption after massive intestinal resection. SUMMARY BACKGROUND DATA: Patients with the short bowel syndrome are maintained on long-term total parenteral nutrition (TPN) or more frequently considered for intestinal transplantation as part of their treatment program. The authors have administered a combination of trophic agents and a specialized diet to further enhance intestinal compensation and optimize nutrient absorption in patients with intestinal failure.
methodsForty-five TPN-dependent adults with a jejunal-ileal remnant < or = 50 cm and a portion of colon in continuity were treated with growth hormone, glutamine, and a modified diet for 4 weeks and observed for an average of 1.8 years.
resultsThe average age of the patients was 43 years, the average jejunal-ileal length was 23 cm, and the average length of time the patient received TPN was 4.3 years. After 4 weeks of therapy, 26 (58%) were free of TPN support. Predictors of a favorable response included greater bowel length, lower body weight, and greater bowel length-body weight ratio. At follow-up, the percentage of patients who were not receiving TPN had fallen to 40%.
conclusionsApproximately half of a group of patients, thought to have absorptive surface area inadequate to be independent of TPN support, can maintain themselves on enteral feedings after this intestinal rehabilitation program. Because of the risk, costs, and alterations in lifestyle associated with long-term TPN or intestinal transplantation or both, it seems prudent to consider a program of bowel rehabilitation with an individual patient before embarking on another therapeutic plan.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.