ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Mapping Mammary Tumor Traits in the Rat.Methods in molecular biology (Clifton, N.J.) · 2019Review
- Genetic variation in sensitivity to estrogens and breast cancer risk.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Article
- Development and characterization of a novel rat model of estrogen-induced mammary cancer.Endocrine-related cancer · 2015Article
- CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.Cancer research · 2014Article
- Ept7 influences estrogen action in the pituitary gland and body weight of rats.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
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- Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats.Nutrition & metabolism · 2010Article
- Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat.Endocrinology · 2008Article
- Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
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- Article
- Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction.Endocrine · 2003Article
- Strain differences in vaginal responses to the xenoestrogen bisphenol A.Environmental health perspectives · 2000Article
- Estrogen action in the regulation of cell proliferation, cell survival, and tumorigenesis in the rat anterior pituitary gland.Endocrine · 1999Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Growth control is of fundamental importance to biology in general and of critical importance to cancer research in particular. Tumors develop when control of the normal growth process is lost. The rat pituitary is a model system for control of estrogen-dependent growth. Chronic estrogen treatment induces uncontrolled growth in the pituitaries of Fischer 344 (F344) rats, but not of Brown Norway (BN) rats. We have identified five quantitative trait loci (QTL) for estrogen-dependent pituitary mass (Edpm) in an F2 intercross of F344 and BN. These QTL reside on rat Chromosomes (Chrs) 2, 3, 5, and 9 and explain a total of 55% of the genetic variance in the F2. We have also detected suggestive evidence for a QTL on rat Chr 14. For Edpm2-1, Edpm2-2, Edpm3, and Edpm5, the F344 allele corresponds with increased pituitary mass, as expected. Surprisingly, for Edpm9 and the suggested QTL on Chr 14, the BN allele corresponds with increased pituitary mass. We also find evidence for interaction (epistasis) between Edpm3 and Edpm9 and between Edpm5 and the suggested QTL on Chr 14.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.