ArticleNucleic acids research1997
Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Eosinophils Protect Mice From Angiotensin-II Perfusion-Induced Abdominal Aortic Aneurysm.Circulation research · 2021Article
- Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis.The Journal of allergy and clinical immunology · 2020Article
- Mapping, phylogenetic and expression analysis of the RNase (RNase A) locus in cattle.Journal of molecular evolution · 2012Article
- Eosinophils in innate immunity: an evolving story.Cell and tissue research · 2011Review
- Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodents.Journal of molecular evolution · 2004Article
- Divergence of spatial gene expression profiles following species-specific gene duplications in human and mouse.Genome research · 2004Article
- Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated ribonuclease 2 (mEar 2) gene.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- The structural integrity exerted by N-terminal pyroglutamate is crucial for the cytotoxicity of frog ribonuclease from Rana pipiens.Nucleic acids research · 2003Article
- Article
- Evolution of the rodent eosinophil-associated RNase gene family by rapid gene sorting and positive selection.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Eosinophils, ribonucleases and host defense: solving the puzzle.Immunologic research · 1999Review
- Positive Darwinian selection after gene duplication in primate ribonuclease genes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have characterized four novel murine ribonuclease genes that, together with the murine eosinophil-associated ribonucleases 1 and 2, form a distinct and unusual cluster within the RNase A gene superfamily. Three of these genes (mR-3, mR-4, mR-5) include complete open reading frames, encoding ribonucleases with eight cysteines and appropriately spaced histidines (His11 and His124) and lysine (Lys35) that are characteristic of this enlarging protein family; the fourth sequence encodes a non-functional pseudogene (mR-6P). Although the amino acid sequence similarities among these murine ribonucleases varies from 60 to 94%, they form a unique cluster, as each sequence is found to be more closely related to another of this group than to either murine angiogenin or to murine pancreatic ribonuclease. Interestingly, the relationship between the six genes in this 'mR cluster' and the defined lineages of the RNase A gene family could not be determined by amino acid sequence homology, suggesting the possibility that there are one or more additional ribonuclease lineages that have yet to be defined. Although the nature of the evolutionary constraints promoting this unusual expansion and diversification remain unclear, the implications with respect to function are intriguing.
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