ArticleBiophysical journal1997
Proximity oscillations of complement type 4 (alphaX beta2) and urokinase receptors on migrating neutrophils.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 81 citations in OpenAlex.
- Leukocyte pyruvate kinase expression is reduced in normal human pregnancy but not in pre-eclampsia.American journal of reproductive immunology (New York, N.Y. : 1989) · 2010Article
- The tripeptide feG inhibits leukocyte adhesion.Journal of inflammation (London, England) · 2008Article
- Neutrophils: the forgotten cell in JIA disease pathogenesis.Pediatric rheumatology online journal · 2007Article
- Elevated glucose concentrations promote receptor-independent activation of adherent human neutrophils: an experimental and computational approach.Biophysical journal · 2007Article
- Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Ion channel clustering enhances weak electric field detection by neutrophils: apparent roles of SKF96365-sensitive cation channels and myeloperoxidase trafficking in cellular responses.European biophysics journal : EBJ · 2005Article
- Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments.The Journal of general physiology · 2004Article
- Fluorescence spectroscopic detection of mitochondrial flavoprotein redox oscillations and transient reduction of the NADPH oxidase-associated flavoprotein in leukocytes.European biophysics journal : EBJ · 2004Article
- Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator.Histochemistry and cell biology · 2004Article
- Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils.The Journal of clinical investigation · 2002Article
- Interactions of integrins with their partner proteins in leukocyte membranes.Immunologic research · 2002Review
- Plasmin-dependent elimination of the growth-factor-like domain in urokinase causes its rapid cellular uptake and degradation.The Biochemical journal · 2001Article
- Article
- Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin.The Journal of cell biology · 2001Article
- Dissipative metabolic patterns respond during neutrophil transmembrane signaling.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Neutrophil oscillations: temporal and spatiotemporal aspects of cell behavior.Immunologic research · 2001Review
- Interferon-gamma and sinusoidal electric fields signal by modulating NAD(P)H oscillations in polarized neutrophils.Biophysical journal · 2000Article
- Cellular memory: neutrophil orientation reverses during temporally decreasing chemoattractant concentrations.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Oscillatory pericellular proteolysis and oxidant deposition during neutrophil locomotion.Biophysical journal · 1998Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Migrating neutrophils utilize beta2 integrins for substrate attachment and urokinase receptors (uPAR) to focus pericellular proteolysis. Our studies show that CR3 associates with uPAR on resting cells, whereas uPAR associates with CR4 at lamellipodia of migrating cells. Using resonance energy transfer (RET) microscopy, we show that the molecular proximity between CR4 and uPAR oscillates on migrating cells, thus suggesting that CR4 molecules periodically bind/release uPAR. Cell contact with fibrinogen, endothelial cells, chemotactic factors and indomethacin, and treatment with sub-optimal doses of signal transduction inhibitors, affect the oscillations' period, amplitude, and/or waveform. The oscillations were indistinguishable in period and 180 degrees out-of-phase with cytosolic NAD(P)H autofluorescence oscillations. Thus, CR4 and CR3 identify a neutrophil's axis of migration and CR4 may restrain uPAR at lamellipodia. Oscillations in signal transduction and energy metabolism may coordinate cell adherence, local proteolysis, oxidant release, actin assembly, and cell extension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.