ArticleGenetics1997
High frequency cDNA recombination of the saccharomyces retrotransposon Ty5: The LTR mediates formation of tandem elements.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Tandem LTR-retrotransposon structures are common and highly polymorphic in plant genomes.Mobile DNA · 2025Article
- Identification of an integrase-independent pathway of retrotransposition.Science advances · 2022Article
- Rapid evolution at the Drosophila telomere: transposable element dynamics at an intrinsically unstable locus.Genetics · 2021Article
- Double insertion of transposable elements provides a substrate for the evolution of satellite DNA.Genome research · 2018Article
- SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast.PLoS genetics · 2007Article
- Molecular characterization and genomic distribution of Isis: a new retrotransposon of Drosophila buzzatii.Molecular genetics and genomics : MGG · 2007Article
- Variability, recombination, and mosaic evolution of the barley BARE-1 retrotransposon.Journal of molecular evolution · 2005Article
- Article
- Controlling integration specificity of a yeast retrotransposon.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Ty5 gag mutations increase retrotransposition and suggest a role for hydrogen bonding in the function of the nucleocapsid zinc finger.Journal of virology · 2002Article
- Coupling of enhancer and insulator properties identified in two retrotransposons modulates their mutagenic impact on nearby genes.Molecular and cellular biology · 2002Article
- The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.Genome biology · 2002Article
- Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p.Molecular and cellular biology · 2001Article
- Expression and processing of proteins encoded by the Saccharomyces retrotransposon Ty5.Journal of virology · 2001Article
- Tagging chromatin with retrotransposons: target specificity of the Saccharomyces Ty5 retrotransposon changes with the chromosomal localization of Sir3p and Sir4p.Genes & development · 1999Article
- The yeast retrotransposon Ty5 uses the anticodon stem-loop of the initiator methionine tRNA as a primer for reverse transcription.RNA (New York, N.Y.) · 1999Article
- cDNA of the yeast retrotransposon Ty5 preferentially recombines with substrates in silent chromatin.Molecular and cellular biology · 1999Article
- Schizosaccharomyces pombe retrotransposon Tf2 mobilizes primarily through homologous cDNA recombination.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retroelement cDNA can integrate into the genome using the element-encoded integrase or it can recombine with preexisting elements using the recombination system of the host. Recombination is a particularly important pathway for the yeast retrotransposon Ty5 and accounts for approximately 30% of the putative transposition events when a homologous substrate is carried on a plasmid and approximately 7% when the substrate is located at the chromosomal URA3 locus. Characterization of recombinants revealed that they are either simple replacements of the marker gene tandem elements. Using an assay system in which the donor element and recombination substrates are separated, we found that the long terminal repeats (LTRs) are critical for tandem element formation. LTR-containing substrates generate tandem elements at frequencies more than 10-fold higher than similarly sized internal Ty5 sequences. Internal sequences, however, facilitate tandem element formation when associated with an LTR, and there is a linear relationship between frequencies of tandem element formation and the length of LTR-containing substrates. We propose that recombination is initiated between the LTRs of the cDNA and substrate and that internal sequences promote tandem element formation by facilitating sequence alignment. Because of its location in subtelomeric regions, recombinational amplification of Ty5 may contribute to the organizations of chromosome ends.
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