ArticleGenetics1997
Identification of genes controlling growth polarity in the budding yeast Saccharomyces cerevisiae: a possible role of N-glycosylation and involvement of the exocyst complex.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 82 citations in OpenAlex.
- Identification and functional characterization of Candida albicans mannose-ethanolamine phosphotransferase (Mcd4p).Current genetics · 2019Article
- Impaired manganese metabolism causes mitotic misregulation.The Journal of biological chemistry · 2012Article
- B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast.PLoS genetics · 2010Article
- The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion.Molecular biology of the cell · 2008Article
- Influence of N-glycosylation on Saccharomyces cerevisiae morphology: a golgi glycosylation mutant shows cell division defects.Current microbiology · 2007Article
- Guanylic nucleotide starvation affects Saccharomyces cerevisiae mother-daughter separation and may be a signal for entry into quiescence.BMC cell biology · 2005Article
- Schizosaccharomyces pombe Pmr1p is essential for cell wall integrity and is required for polarized cell growth and cytokinesis.Eukaryotic cell · 2004Article
- Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function.The Journal of cell biology · 2004Article
- The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p.Molecular biology of the cell · 2002Article
- Molecular and phenotypic analysis of CaVRG4, encoding an essential Golgi apparatus GDP-mannose transporter.Journal of bacteriology · 2002Article
- F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat.Molecular and cellular biology · 2001Article
- A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1.The Journal of cell biology · 2001Article
- Article
- The role of the COOH terminus of Sec2p in the transport of post-Golgi vesicles.The Journal of cell biology · 2000Article
- Molecular analysis of the Candida albicans homolog of Saccharomyces cerevisiae MNN9, required for glycosylation of cell wall mannoproteins.Journal of bacteriology · 1999Article
- Chitin synthase III: synthetic lethal mutants and "stress related" chitin synthesis that bypasses the CSD3/CHS6 localization pathway.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.Molecular biology of the cell · 1999Article
- The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis.The EMBO journal · 1999Article
- A morphogenesis checkpoint monitors the actin cytoskeleton in yeast.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The regulation of secretion polarity and cell surface growth during the cell cycle is critical for proper morphogenesis and viability of Saccharomyces cerevisiae. A shift from isotropic cell surface growth to polarized growth is necessary for bud emergence and a repolarization of secretion to the bud neck is necessary for cell separation. Although alterations in the actin cytoskeleton have been implicated in these changes in secretion polarity, clearly other cellular systems involved in secretion are likely to be targets of cell cycle regulation. To investigate mechanisms coupling cell cycle progression to changes in secretion polarity in parallel with and downstream of regulation of actin polarization, we implemented a screen for mutants defective specifically in polarized growth but with normal actin cytoskeleton structure. These mutants fell into three classes: those partially defective in N-glycosylation, those linked to specific defects in the exocyst, and a third class neither defective in glycosylation nor linked to the exocyst. These results raise the possibility that changes in N-linked glycosylation may be involved in a signal linking cell cycle progression and secretion polarity and that the exocyst may have regulatory functions in coupling the secretory machinery to the polarized actin cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.