ArticleJournal of bacteriology1997
Identification of an essential Caulobacter crescentus gene encoding a member of the Obg family of GTP-binding proteins.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Ectopic overexpression and CRISPRi-based knockdown ofJournal of bacteriology · 2025Article
- RiceG3 (Bethesda, Md.) · 2018Article
- Characterization of the autophosphorylation property of HflX, a ribosome-binding GTPase from Escherichia coli.FEBS open bio · 2016Article
- BcMtg2 is required for multiple stress tolerance, vegetative development and virulence in Botrytis cinerea.Scientific reports · 2016Article
- Article
- The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target.BMC microbiology · 2015Article
- The universally conserved prokaryotic GTPases.Microbiology and molecular biology reviews : MMBR · 2011Review
- Biochemical and physiological characterization of the GTP-binding protein Obg of Mycobacterium tuberculosis.BMC microbiology · 2011Article
- Molecular modeling study for interaction between Bacillus subtilis Obg and Nucleotides.PloS one · 2010Article
- AtObgC, a plant ortholog of bacterial Obg, is a chloroplast-targeting GTPase essential for early embryogenesis.Plant molecular biology · 2009Article
- SpoT regulates DnaA stability and initiation of DNA replication in carbon-starved Caulobacter crescentus.Journal of bacteriology · 2008Article
- The growth-promoting and stress response activities of the Bacillus subtilis GTP binding protein Obg are separable by mutation.Journal of bacteriology · 2008Article
- Functional analysis of the essential GTP-binding-protein-coding gene cgtA of Vibrio cholerae.Journal of bacteriology · 2008Article
- Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The Escherichia coli GTPase CgtAE is involved in late steps of large ribosome assembly.Journal of bacteriology · 2006Article
- The Vibrio harveyi GTPase CgtAV is essential and is associated with the 50S ribosomal subunit.Journal of bacteriology · 2006Article
- The Escherichia coli GTPase CgtAE cofractionates with the 50S ribosomal subunit and interacts with SpoT, a ppGpp synthetase/hydrolase.Journal of bacteriology · 2004Article
- Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid.Journal of bacteriology · 2003Article
- hetL overexpression stimulates heterocyst formation in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2002Article
- Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified an essential Caulobacter crescentus gene (cgtA) that encodes a member of a recently identified subfamily of GTPases (the Obg family) conserved from Bacteria to Archaea to humans. This evolutionary conservation between distantly related species suggests that this family of GTP-binding proteins possesses a fundamental, yet unknown, cellular role. In this report, we describe the isolation and sequence of the cgtA gene. The predicted CgtA protein displays striking similarity to the Obg family of small, monomeric GTP-binding proteins, both in the conserved guanine nucleotide-binding domains and throughout the N-terminal glycine-rich domain that is found in many members of the Obg family. Disruption of the cgtA gene was lethal, demonstrating that this gene is essential for cell growth. Immunoblot analysis revealed that CgtA protein levels remained constant throughout the C. crescentus cell cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.