ArticleJournal of bacteriology1997
Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tü57.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 111 citations in OpenAlex.
- Sequential Reconstruction of Calicheamicin γAngewandte Chemie (International ed. in English) · 2025Article
- An NADH/NADApplied and environmental microbiology · 2024Article
- Characterization of Dichloroisoeverninic Acid Biosynthesis and Chemoenzymatic Synthesis of New Orthosomycins.ACS chemical biology · 2024Article
- The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases.Communications biology · 2022Article
- Identification of a lichen depside polyketide synthase gene by heterologous expression inMetabolic engineering communications · 2021Article
- Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides.Microbial cell factories · 2021Review
- Microbial Oligosaccharides with Biomedical Applications.Marine drugs · 2021Review
- Oxidative Cyclization in Natural Product Biosynthesis.Chemical reviews · 2017Review
- Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway.Nature communications · 2016Article
- Iterative polyketide biosynthesis by modular polyketide synthases in bacteria.Applied microbiology and biotechnology · 2016Review
- Structural Characterization of CalS8, a TDP-α-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.The Journal of biological chemistry · 2015Article
- An in planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum.Applied and environmental microbiology · 2015Article
- Bioactive oligosaccharide natural products.Natural product reports · 2014Review
- Genome based analysis of type-I polyketide synthase and nonribosomal peptide synthetase gene clusters in seven strains of five representative Nocardia species.BMC genomics · 2014Article
- Draft Genome Sequence of Streptomyces viridochromogenes Strain Tu57, Producer of Avilamycin.Genome announcements · 2013Article
- Phylogenomic and domain analysis of iterative polyketide synthases in Aspergillus species.Evolutionary bioinformatics online · 2012Article
- Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway.Acta crystallographica. Section D, Biological crystallography · 2011Article
- Methods and options for the heterologous production of complex natural products.Natural product reports · 2011Review
- Cyclization of aromatic polyketides from bacteria and fungi.Natural product reports · 2010Review
- Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 65-kb region of DNA from Streptomyces viridochromogenes Tü57, containing genes encoding proteins involved in the biosynthesis of avilamycins, was isolated. The DNA sequence of a 6.4-kb fragment from this region revealed four open reading frames (ORF1 to ORF4), three of which are fully contained within the sequenced fragment. The deduced amino acid sequence of AviM, encoded by ORF2, shows 37% identity to a 6-methylsalicylic acid synthase from Penicillium patulum. Cultures of S. lividans TK24 and S. coelicolor CH999 containing plasmids with ORF2 on a 5.5-kb PstI fragment were able to produce orsellinic acid, an unreduced version of 6-methylsalicylic acid. The amino acid sequence encoded by ORF3 (AviD) is 62% identical to that of StrD, a dTDP-glucose synthase from S. griseus. The deduced amino acid sequence of AviE, encoded by ORF4, shows 55% identity to a dTDP-glucose dehydratase (StrE) from S. griseus. Gene insertional inactivation experiments of aviE abolished avilamycin production, indicating the involvement of aviE in the biosynthesis of avilamycins.
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Registered trials
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