ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Modulation of intrinsic circuits by serotonin 5-HT3 receptors in developing ferret visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Central Post-Stroke Pain: An Integrative Review of Somatotopic Damage, Clinical Symptoms, and Neurophysiological Measures.Frontiers in neurology · 2021Pooled it
- 5-HTCurrent neuropharmacology · 2021Pooled it
- Effect of serotonin on paired associative stimulation-induced plasticity in the human motor cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Escitalopram Decreases Cross-Regional Functional Connectivity within the Default-Mode Network.PloS one · 2013Trial
- Decrease of serotonin transporters in blood platelets after epileptic seizures.Neurochemical research · 2005Trial
- Serotonergic Modulation of the Excitation/Inhibition Balance in the Visual Cortex.International journal of molecular sciences · 2023Article
- Effects of chronic antidepressant use on neurophysiological responses to tDCS post-stroke.Neuroscience letters · 2020Article
- Role of cortical spreading depression in the pathophysiology of migraine.Neuroscience bulletin · 2014Review
- Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus.Hearing research · 2009Article
- Serotonergic modulation of plasticity of the auditory cortex elicited by fear conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Effects of neurotrophins on cortical plasticity: same or different?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Noradrenergic excitation and inhibition of GABAergic cell types in rat frontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Investigating the Serotonergic Modulation of Orientation Tuning of Neurons in Primary Visual Cortex of Anesthetized Mice.Basic and clinical neuroscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Serotonergic projections are widespread in the developing neocortex, but their functions are obscure. The effects of 5-HT3 receptor agonists on cortical circuit response properties were studied in slices of ferret primary visual cortex using high-speed optical imaging of voltage-sensitive dye signals and whole-cell patch-clamp recording. Activation of the 5-HT3 receptor decreased the amplitude and lateral extent of excitation throughout postnatal development. This effect peaks after eye opening, which indicates a function for serotonergic modulation of circuit responses during the period of refinement of cortical connections. Whole-cell patch-clamp recordings from single neurons revealed that synaptic responses evoked by white matter stimulation were reduced by 5-HT3 receptor agonists, whereas the frequency of spontaneous GABAergic synaptic currents was enhanced dramatically. This indicates that the modulation of spontaneous synaptic activity by fast-acting serotonin receptors is reflected in an inhibition of the circuit response, in line with the notion of background synaptic activity altering the spatiotemporal integration properties of cortical cells by changing their membrane potential and their electrotonic structure. These mechanisms may regulate the response properties of intrinsic circuits in both the adult and developing neocortex.
Indexed as
Identifiers
9334407PMC6573753W1851387472What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.