ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 114 citations in OpenAlex.
- Transcription of Clock Genes in Medulloblastoma.Cancers · 2025Article
- Photoreceptor phosphodiesterase (PDE6): activation and inactivation mechanisms during visual transduction in rods and cones.Pflugers Archiv : European journal of physiology · 2021Review
- Exposure to Artificial Light at Night and the Consequences for Flora, Fauna, and Ecosystems.Frontiers in neuroscience · 2020Review
- Dim Light at Night and Constant Darkness: Two Frequently Used Lighting Conditions That Jeopardize the Health and Well-being of Laboratory Rodents.Frontiers in neurology · 2018Review
- Peripheral Sensory Neurons Expressing Melanopsin Respond to Light.Frontiers in neural circuits · 2016Article
- Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation.PloS one · 2015Article
- Homeobox genes and melatonin synthesis: regulatory roles of the cone-rod homeobox transcription factor in the rodent pineal gland.BioMed research international · 2014Review
- Estrogen-related receptor β deficiency alters body composition and response to restraint stress.BMC physiology · 2013Article
- Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance.Neurochemical research · 2013Review
- Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control.Translational psychiatry · 2013Article
- Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression.The European journal of neuroscience · 2013Article
- Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina.PloS one · 2013Article
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- G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.Pharmacology & therapeutics · 2012Review
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- Shadow response in the blind cavefish Astyanax reveals conservation of a functional pineal eye.The Journal of experimental biology · 2008Article
- Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells.BMC developmental biology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Whereas the pineal organs of lower vertebrates have been shown to be photosensitive, photic regulation of pineal function in adult mammals is thought be mediated entirely by retinal photoreceptors. Extraretinal regulation of pineal function has been reported in neonatal rodents, although both the site and molecular basis of extraretinal photoreception have remained obscure. In this study we examine the developmental expression pattern of all of the principal components of retinal phototransduction in rat pineal via cRNA in situ hybridization. All of the components needed to reconstitute a functional phototransduction pathway are expressed in the majority of neonatal pinealocytes, although the expression levels of many of these genes decline dramatically during development. These findings strongly support the theory that the neonatal rat pineal itself is photosensitive. In addition, we observe in neonatal pinealocytes the expression of both rod-specific and cone-specific phototransduction components, implying the existence of functionally different subtypes of pinealocytes that express varying combinations of phototransduction enzymes.
Indexed as
Identifiers
9334383PMC6573733W2161513421What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.