ArticleThe Journal of experimental medicine1997
Suppression of leukotriene B4 biosynthesis by endogenous adenosine in ligand-activated human neutrophils.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming.Developmental cell · 2024Article
- A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling.Purinergic signalling · 2022Review
- The immunomodulatory function of adenosine in sepsis.Frontiers in immunology · 2022Review
- Phosphorylation of 5-LOX: The Potential Set-point of Inflammation.Neurochemical research · 2020Review
- Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues.Biochemical and biophysical research communications · 2018Review
- Impaired Production and Diurnal Regulation of Vascular RvDCirculation research · 2018Article
- The hypoxia-adenosine link during inflammation.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Purinergic signalling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury.Purinergic signalling · 2017Review
- A cluster of immunoresolvents links coagulation to innate host defense in human blood.Science signaling · 2017Article
- Crosstalk between purinergic receptors and lipid mediators in leishmaniasis.Parasites & vectors · 2016Review
- Purinergic signalling and immune cells.Purinergic signalling · 2014Review
- Regulation of neutrophil function by adenosine.Arteriosclerosis, thrombosis, and vascular biology · 2012Review
- Article
- Transfusion-related acute lung injury (TRALI): current concepts and misconceptions.Blood reviews · 2009Review
- Article
- Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils.Biochimica et biophysica acta · 2007Article
- Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils.British journal of pharmacology · 2006Article
- Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal.Journal of cell science · 2005Article
- Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.British journal of pharmacology · 2004Article
- Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation.The Journal of experimental medicine · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenosine (Ado) has been shown to suppress several functional responses of human polymorphonuclear leukocytes (PMNs). The current study investigated whether endogenous Ado regulates the biosynthesis of leukotriene (LT)B4 in ligand-stimulated PMNs. Measurements of Ado in PMN resuspended in Hanks' buffered salt solution (HBSS) or plasma showed a cell concentration- and time-dependent accumulation of the nucleoside. The removal of endogenous Ado with either Ado deaminase or the blockade of its action by the Ado A2a receptor antagonist, 8-(3-chlorostyryl) caffeine, markedly increased LTB4 biosynthesis upon ligand stimulation in HBSS. Similarly, LTB4 synthesis by ligand-stimulated PMNs in plasma (containing recombinant LTA4 hydrolase to allow the conversion of protein-bound LTA4) was strongly enhanced by addition of Ado deaminase. Addition of red blood cells to suspensions of PMNs in plasma mimicked the effect of adding Ado deaminase and LTA4 hydrolase in enhancing LTB4 biosynthesis upon ligand stimulation. This effect of red blood cells on LTB4 biosynthesis was blocked by dipyridamole, an inhibitor of Ado transport, or captopril, an inhibitor of LTA4 hydrolase. These results demonstrate that endogenous Ado efficiently downregulates ligand-stimulated LTB4 biosynthesis in PMN suspensions, pointing out a potentially important regulatory function of Ado in inflammatory exudates. These results also unveil a dual role for red blood cells in upregulating LTB4 biosynthesis, namely, the removal of endogenous Ado and the conversion of LTA4 released by activated PMNs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.