ArticleThe Journal of experimental medicine1997
Negative regulation of Fc epsilon RI-mediated degranulation by CD81.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Tetraspanins in the regulation of mast cell function.Medical microbiology and immunology · 2020Review
- Tetraspanins and Transmembrane Adaptor Proteins As Plasma Membrane Organizers-Mast Cell Case.Frontiers in cell and developmental biology · 2016Review
- Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Article
- The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.The Journal of biological chemistry · 2013Article
- Tetraspanins in mast cells.Frontiers in immunology · 2012Article
- Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin.Journal of cell science · 2009Article
- The first transmembrane region of the beta-chain stabilizes the tetrameric Fc epsilon RI complex.Molecular immunology · 2009Article
- The nuclear membrane organization of leukotriene synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis.The Journal of experimental medicine · 2008Article
- Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels.Nature immunology · 2008Article
- The long and arduous road to CRAC.Cell calcium · 2007Review
- Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor.Blood · 2006Article
- Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo.The Journal of experimental medicine · 2005Article
- Role of secretory carrier membrane protein SCAMP2 in granule exocytosis.Molecular biology of the cell · 2002Article
- Signal transduction-associated and cell activation-linked antigens expressed in human mast cells.International journal of hematology · 2002Review
- Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein.The Journal of experimental medicine · 2002Article
- Article
- Antibody cross-linking of human CD9 and the high-affinity immunoglobulin E receptor stimulates secretion from transfected rat basophilic leukaemia cells.Immunology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Signaling through the high affinity receptor for immunoglobulin E (Fc epsilon RI) results in the coordinate activation of tyrosine kinases before calcium mobilization. Receptors capable of interfering with the signaling of antigen receptors, such as Fc epsilon RI, recruit tyrosine and inositol phosphatases that results in diminished calcium mobilization. Here, we show that antibodies recognizing CD81 inhibit Fc epsilon RI-mediated mast cell degranulation but, surprisingly, without affecting aggregation-dependent tyrosine phosphorylation, calcium mobilization, or leukotriene synthesis. Furthermore, CD81 antibodies also inhibit mast cell degranulation in vivo as measured by reduced passive cutaneous anaphylaxis responses. These results reveal an unsuspected calcium-independent pathway of antigen receptor regulation, which is accessible to engagement by membrane proteins and on which novel therapeutic approaches to allergic diseases could be based.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.