ArticleGenes & development1997
TAFII250-dependent transcription of cyclin A is directed by ATF activator proteins.
Article in Genes & development, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 87 citations in OpenAlex.
- Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4-TAF6 axis in the cell cycle.Cell death & disease · 2025Article
- Zinc knuckle of TAF1 is a DNA binding module critical for TFIID promoter occupancy.Scientific reports · 2018Article
- Targeting TBP-Associated Factors in Ovarian Cancer.Frontiers in oncology · 2014Review
- Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity.BMC pharmacology & toxicology · 2013Article
- BET domain co-regulators in obesity, inflammation and cancer.Nature reviews. Cancer · 2012Review
- Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation.Discovery medicine · 2010Review
- An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.FEBS letters · 2010Review
- Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis.The Journal of biological chemistry · 2007Article
- Genome-wide relationships between TAF1 and histone acetyltransferases in Saccharomyces cerevisiae.Molecular and cellular biology · 2006Article
- Functional characterization of core promoter elements: the downstream core element is recognized by TAF1.Molecular and cellular biology · 2005Article
- Article
- TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter.Molecular and cellular biology · 2005Article
- Activation of a DNA damage checkpoint response in a TAF1-defective cell line.Molecular and cellular biology · 2004Article
- SRC proximal and core promoter elements dictate TAF1 dependence and transcriptional repression by histone deacetylase inhibitors.Molecular and cellular biology · 2004Article
- Article
- GAGA can mediate enhancer function in trans by linking two separate DNA molecules.The EMBO journal · 2002Article
- Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.Journal of virology · 2002Article
- Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells.Oncogene · 2002Article
- Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription.The EMBO journal · 2001Article
- Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A specific mutation in TAFII250, the largest subunit of the transcription factor TFIID, disrupts cell growth control in the temperature-sensitive mutant hamster cell line ts13. Transcription from the cyclin A and D1 but not the c-fos and myc promoters is also dramatically reduced in ts13 cells at the nonpermissive temperature. These findings provide an intriguing link between TAF-mediated transcriptional regulation and cell cycle progression. Here we report the mapping of an enhancer element in the cyclin A promoter (TSRE) that responds to mutations in TAFII250. An analysis of chimeric promoter constructs reveals that the cyclin A TSRE can confer TAFII250 dependence to the core promoter of c-fos. In addition, reciprocal hybrid promoter constructs suggest that TAFII250 also contributes to the transcriptional properties of the cyclin A core promoter. We have purified and identified cellular activators that specifically bind to the TSRE and mediate transcription in a TAFII250-dependent manner. By micropeptide sequencing, we determined that TSRE-binding proteins include members of the activating transcription factor (ATF) family. These results suggest that the ts13 mutation of TAFII250 has compromised the ability of TFIID to mediate activation of transcription by specific enhancer factors such as ATF, as well as to perform certain core promoter functions. These defects in TAFII250 apparently result in the down-regulation of key molecules, such as cyclin A, which may be responsible for the ts13 cell cycle arrest phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.