ArticleGenes & development1997
Intergenic transcription and transinduction of the human beta-globin locus.
Article in Genes & development, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
155 citing papers in PubMed, 328 citations in OpenAlex.
- Enhancer RNA transcription near segmentation gene enhancers can be analyzed in situ using FISH.G3 (Bethesda, Md.) · 2026Article
- Transcriptional coordination between intergenic RNA polymerase II-bound regions and nearby genes reveals functional specialization and disease associations in peripheral blood.Computational and structural biotechnology journal · 2025Article
- Active enhancers: recent research advances and insights into disease.Biology direct · 2024Review
- Understanding fundamental principles of enhancer biology at a model locus: Analysing the structure and function of an enhancer cluster at the α-globin locus.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Review
- Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases.Cell communication and signaling : CCS · 2023Review
- Enhancer-Mediated Formation of Nuclear Transcription Initiation Domains.International journal of molecular sciences · 2022Review
- Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions.Nucleic acids research · 2022Article
- The activity of human enhancers is modulated by the splicing of their associated lncRNAs.PLoS computational biology · 2022Article
- Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops.Frontiers in cell and developmental biology · 2022Article
- Systematic functional characterization of antisense eRNA of protocadherinGenes & development · 2021Article
- Genome-wide strand asymmetry in massively parallel reporter activity favors genic strands.Genome research · 2021Article
- Mechanisms of enhancer action: the known and the unknown.Genome biology · 2021Review
- Super-enhancer mediated regulation of adult β-globin gene expression: the role of eRNA and Integrator.Nucleic acids research · 2021Article
- Spirits in the Material World: Enhancer RNAs in Transcriptional Regulation.Trends in biochemical sciences · 2021Review
- Transcriptionally active enhancers in human cancer cells.Molecular systems biology · 2021Article
- Review
- Nascent RNA analyses: tracking transcription and its regulation.Nature reviews. Genetics · 2019Review
- The Emerging Role of Major Regulatory RNAs in Cancer Control.Frontiers in oncology · 2019Review
- Beyond the Exome: The Non-coding Genome and Enhancers in Neurodevelopmental Disorders and Malformations of Cortical Development.Frontiers in cellular neuroscience · 2019Article
- An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain.PloS one · 2019Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We have identified novel nuclear transcripts in the human beta-globin locus using nuclear run-on analysis in erythroid cell lines and in situ hybridization analysis of erythroid tissue. These transcripts extend across the LCR and intergenic regions but are undetectable in nonerythroid cells. Surprisingly, transient transfection of a beta-globin gene (epsilon, gamma, or beta) induces transcription of the LCR and intergenic regions from the chromosomal beta-globin locus in nonerythroid cell lines. The beta-globin genes themselves, however, remain transcriptionally silent. Induction is dependent on transcription of the globin gene in the transfected plasmid but does not require protein expression. Using in situ hybridization analysis, we show that the plasmid colocalizes with the endogenous beta-globin locus providing insight into the mechanism of transinduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.