ArticleDigestive diseases and sciences1997
Tachykinins influence interdigestive rhythm and contractile strength of human small intestine.
Article in Digestive diseases and sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Trial
- A novel tachykinin NK2 receptor antagonist prevents motility-stimulating effects of neurokinin A in small intestine.British journal of pharmacology · 2001Trial
- Motilin- and neuropeptide Y-like immunoreactivity in a psychophysiological stress experiment on patients with functional dyspepsia.Integrative physiological and behavioral science : the official journal of the Pavlovian SocietyTrial
- Recent Developments in On-Demand Voiding Therapies.The Journal of pharmacology and experimental therapeutics · 2024Review
- The Influence of Bisphenol A (BPA) on the Occurrence of Selected Active Substances in Neuregulin 1 (NRG1)-Positive Enteric Neurons in the Porcine Large Intestine.International journal of molecular sciences · 2021Article
- Mycotoxins and the Enteric Nervous System.Toxins · 2020Review
- Prokinetic effects of the neurokinin NK2 receptor agonist [LysNeuropeptides · 2019Article
- Colorectal and cardiovascular effects of [LysNaunyn-Schmiedeberg's archives of pharmacology · 2018Article
- NK2 and NK1 receptor-mediated effects of NKA and analogs on colon, bladder, and arterial pressure in anesthetized dogs.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Changes in Immunoreactivity of Sensory Substances within the Enteric Nervous System of the Porcine Stomach during Experimentally Induced Diabetes.Journal of diabetes research · 2018Article
- Co-localization of zinc transporter 3 (ZnT3) with sensory neuromediators and/or neuromodulators in the enteric nervous system of the porcine esophagus.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2017Article
- Pharmacodynamic evaluation of LysNaunyn-Schmiedeberg's archives of pharmacology · 2017Article
- The Influence of Low Doses of Zearalenone on Distribution of Selected Active Substances in Nerve Fibers Within the Circular Muscle Layer of Porcine Ileum.Journal of molecular neuroscience : MN · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of the putative enteric neurotransmitters neurokinin A and substance P were investigated on human small intestinal motility. Either neurokinin A, at doses of 6-25 pmol/kg/min, or substance P at doses of 1-6 pmol/kg/min were administered intravenously to healthy volunteers over 4 hr. Neurokinin A dose-dependently increased the fraction of phase II of the migrating motor complex, contraction frequency, motility index, and amplitude of contractions. At the highest dose, neurokinin A induced a phase II-like pattern, disrupting the migrating myoelectric complex. Substance P dose-dependently increased phase II of the migrating motor complex. The contraction frequency increased slightly at the highest dose, but neither motility index nor contraction amplitude changed. It is concluded that neurokinin A and substance P stimulate small intestinal motility in man, and it can be speculated that they play a role in the control of human small intestinal motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.