ReviewDigestive diseases and sciences1997
Recurrence of Helicobacter pylori infection after successful eradication: nature and possible causes.
Review in Digestive diseases and sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Periodontal therapy as adjunctive treatment for gastric Helicobacter pylori infection.The Cochrane database of systematic reviews · 2016Pooled it
- Helicobacter pylori infection in Canadian and related Arctic Aboriginal populations.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2008Pooled it
- H. pylori eradication therapy vs. antisecretory non-eradication therapy (with or without long-term maintenance antisecretory therapy) for the prevention of recurrent bleeding from peptic ulcer.The Cochrane database of systematic reviews · 2004Pooled it
- Long-term follow up Helicobacter Pylori reinfection rate after second-line treatment: bismuth-containing quadruple therapy versus moxifloxacin-based triple therapy.BMC gastroenterology · 2013Trial
- Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection.Infection and immunity · 2001Trial
- Article
- The Puzzle of Coccoid Forms ofAntibiotics (Basel, Switzerland) · 2020Review
- Can Natural Products Suppress ResistanteFood · 2020Article
- Long-term follow-up ofEmerging microbes & infections · 2020Observational
- The Efficacy of Washed Microbiota Transplantation onGastroenterology research and practice · 2020Article
- Gastric malt lymphoma: Analysis of a series of consecutive patients over 20 years.United European gastroenterology journal · 2016Article
- Reinfection after successful eradication of Helicobacter pylori in three different populations in Alaska.Epidemiology and infection · 2015Article
- Helicobacter pylori eradication in West Asia: a review.World journal of gastroenterology · 2014Review
- Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan.BMC gastroenterology · 2013Article
- Helicobacter pylori persistence in children: distinguishing inadequate treatment, resistant organisms, and reinfection.Current gastroenterology reports · 2012Review
- Helicobacter pylori recurrence and infection rate in Israeli adults.Digestive diseases and sciences · 2008Article
- H pylori recurrence after successful eradication.World journal of gastroenterology · 2008Review
- Does seropositivity for Helicobacter pylori antibodies increase outpatient costs for gastric and duodenal ulcer or inflammation?PharmacoEconomics · 2004Article
- Gastric transitional zones, areas where Helicobacter treatment fails: results of a treatment trial using the Sydney strain mouse model.Antimicrobial agents and chemotherapy · 2003Article
- Use of egg yolk-derived immunoglobulin as an alternative to antibiotic treatment for control of Helicobacter pylori infection.Clinical and diagnostic laboratory immunology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrence of Helicobacter pylori infection after successful eradication occurs and is associated with relapse of gastroduodenal diseases. The aims of this paper were to assess the incidence and identify the nature and possible causes of recurrence of the infection. A broad-based Medline search was performed to identify all related publications addressing recurrence of the infection between 1986 and 1995. The 12-month recurrence rate varied among the different studies from 0 to 41.5%. A few studies showed 18- to 24-month recurrence rates, which ranged between 0 and 21.4%. Limited data, obtained using molecular fingerprinting techniques, have shown that in most cases recurrence is due to recrudescence of the original strain; a few cases appear to be due to reinfection with a new strain. Recrudescence is most likely during the first 12 months after apparent eradication. Despite the high sensitivity and specificity of the available individual tests for detecting H. pylori infection in untreated patients, no technique alone is sensitive enough to monitor eradication when the four-week-rule definition for eradication is used. A combination of two or more techniques increases sensitivity. Sensitivity and specificity are increased when biopsies are taken from both gastric antrum and corpus. The best treatments have the lowest recurrence rates and recurrence is rare when the eradication rate is over 90%. Individual susceptibility and reexposure to H. pylori are suggested as two major causes of reinfection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.