ArticleThe Journal of clinical investigation1997
Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 247 citations in OpenAlex.
- Macrophage-stimulated microRNA expression in mural cells promotes transplantation-induced neointima formation.Oncotarget · 2017Article
- Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aorta.British journal of pharmacology · 2017Article
- Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase.Journal of vascular surgery · 2017Article
- My Continuing Evolution as a Surgeon-Scientist: A Decade after the Jacobson Promising Investigator Award.Journal of the American College of Surgeons · 2017Article
- Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein.The Journal of biological chemistry · 2016Article
- Proliferation of macrophages due to the inhibition of inducible nitric oxide synthesis by oxidized low-density lipoproteins.EXCLI journal · 2015Article
- A20-mediated modulation of inflammatory and immune responses in aortic allografts and development of transplant arteriosclerosis.Transplantation · 2012Article
- Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats.The Journal of clinical investigation · 2011Article
- Inducible nitric oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli.American journal of physiology. Heart and circulatory physiology · 2010Article
- Generation of NO by bystander human CD8 T cells augments allogeneic responses by inhibiting cytokine deprivation-induced cell death.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2009Article
- Donor graft interferon regulatory factor-1 gene transfer worsens liver transplant ischemia/reperfusion injury.Surgery · 2009Article
- Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes.Nitric oxide : biology and chemistry · 2008Article
- The complex role of iNOS in acutely rejecting cardiac transplants.Free radical biology & medicine · 2008Review
- Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase.The Journal of clinical investigation · 2004Article
- Mouse models of arteriosclerosis: from arterial injuries to vascular grafts.The American journal of pathology · 2004Review
- Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling.Cell communication and signaling : CCS · 2004Article
- Effects of brief ischemia and reperfusion on the myocardium and the role of nitric oxide.Heart failure reviews · 2003Review
- Cigarette smoking: an important renal risk factor - far beyond carcinogenesis.Tobacco induced diseases · 2002Article
- Nitric oxide inhibits INFgamma-induced increases in CIITA mRNA abundance and activation of CIITA dependent genes--class II MHC, Ii and H-2M. Class II TransActivator.Inflammation · 2000Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
In cardiac transplantation, chronic rejection takes the form of an occlusive vasculopathy. The mechanism underlying this disorder remains unclear. The purpose of this study was to investigate the role nitric oxide (NO) may play in the development of allograft arteriosclerosis. Rat aortic allografts from ACI donors to Wistar Furth recipients with a strong genetic disparity in both major and minor histocompatibility antigens were used for transplantation. Allografts collected at 28 d were found to have significant increases in both inducible NO synthase (iNOS) mRNA and protein as well as in intimal thickness when compared with isografts. Inhibiting NO production with an iNOS inhibitor increased the intimal thickening by 57.2%, indicating that NO suppresses the development of allograft arteriosclerosis. Next, we evaluated the effect of cyclosporine (CsA) on iNOS expression and allograft arteriosclerosis. CsA (10 mg/kg/d) suppressed the expression of iNOS in response to balloon-induced aortic injury. Similarly, CsA inhibited iNOS expression in the aortic allografts, associated with a 65% increase in intimal thickening. Finally, we investigated the effect of adenoviral-mediated iNOS gene transfer on allograft arteriosclerosis. Transduction with iNOS using an adenoviral vector suppressed completely the development of allograft arteriosclerosis in both untreated recipients and recipients treated with CsA. These results suggest that the early immune-mediated upregulation in iNOS expression partially protects aortic allografts from the development of allograft arteriosclerosis, and that iNOS gene transfer strategies may prove useful in preventing the development of this otherwise untreatable disease process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.